CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026263
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 HEAT repeat-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 HEATR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34ASLLFDPKEAATIDRubiquitination[1]
167WFWLLPVKQSGVPLAubiquitination[2]
201SLVTKSVKVFAEYPGubiquitination[2]
248KLFPYIQKGLKSSLPubiquitination[3, 4]
385HLEAILTKISLKNNLubiquitination[2]
435LIRLLESKYPRTLDVubiquitination[5, 6]
456KEIADLKKQELFHQFubiquitination[4]
503ILAMNHLKKIMKTSKubiquitination[4]
504LAMNHLKKIMKTSKEubiquitination[4]
510KKIMKTSKEGVDESFubiquitination[4, 6, 7]
519GVDESFIKEAVLARLubiquitination[2, 4, 7]
568FQRAELSKNGEWYEVubiquitination[2, 4, 7]
627KIAIYLSKSGICSLHubiquitination[4]
649EALENVIKSTKPGKLubiquitination[2]
652ENVIKSTKPGKLIGVubiquitination[2]
655IKSTKPGKLIGVANQubiquitination[2]
663LIGVANQKMIELLADubiquitination[4]
801KKFIYALKAPKSFPKubiquitination[2, 4]
905CAMLSSQKTQCKHQLubiquitination[2]
909SSQKTQCKHQLASISubiquitination[4]
932INLGSPVKEVRRAAIubiquitination[2]
1001QKLSETLKNLLSCVYubiquitination[2]
1016SCPSYIAKDLMKVLQubiquitination[2]
1041FAAISDEKVQQKLLRubiquitination[4]
1108RQKMQQKKSQDLESVubiquitination[4]
1184CLLNICQKLSPDGGKubiquitination[2]
1191KLSPDGGKIPKDILDubiquitination[4]
1267YSFQVINKTVKMVIPubiquitination[2, 4]
1402EKEETIPKAVSFNKSubiquitination[3]
1427NVETHTSKQLRHFKFubiquitination[2, 4]
1494NADKLTVKFWRALLSubiquitination[3]
1537PLPSVRRKALDLLNNubiquitination[4]
1545ALDLLNNKLQQNISWubiquitination[2, 4]
1553LQQNISWKKTIVTRFubiquitination[4]
1554QQNISWKKTIVTRFLubiquitination[4]
1562TIVTRFLKLVPDLLAubiquitination[2]
1594QTALYTLKLLCKNFGubiquitination[4]
1598YTLKLLCKNFGAENPubiquitination[4]
1730IRLTSLKKTLATTLAubiquitination[4]
1747VLLPAIKKTYKQIEKubiquitination[4]
1955NRLGGEEKFQERVTKubiquitination[4]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2063 AA 
Protein Sequence
MTSLAQQLQR LALPQSDASL LSRDEVASLL FDPKEAATID RDTAFAIGCT GLEELLGIDP 60
SFEQFEAPLF SQLAKTLERS VQTKAVNKQL DENISLFLIH LSPYFLLKPA QKCLEWLIHR 120
FHIHLYNQDS LIACVLPYHE TRIFVRVIQL LKINNSKHRW FWLLPVKQSG VPLAKGTLIT 180
HCYKDLGFMD FICSLVTKSV KVFAEYPGSS AQLRVLLAFY ASTIVSALVA AEDVSDNIIA 240
KLFPYIQKGL KSSLPDYRAA TYMIICQISV KVTMENTFVN SLASQIIKTL TKIPSLIKDG 300
LSCLIVLLQR QKPESLGKKP FPHLCNVPDL ITILHGISET YDVSPLLHYM LPHLVVSIIH 360
HVTGEETEGM DGQIYKRHLE AILTKISLKN NLDHLLASLL FEEYISYSSQ EEMDSNKVSL 420
LNEQFLPLIR LLESKYPRTL DVVLEEHLKE IADLKKQELF HQFVSLSTSG GKYQFLADSD 480
TSLMLSLNHP LAPVRILAMN HLKKIMKTSK EGVDESFIKE AVLARLGDDN IDVVLSAISA 540
FEIFKEHFSS EVTISNLLNL FQRAELSKNG EWYEVLKIAA DILIKEEILS ENDQLSNQVV 600
VCLLPFMVIN NDDTESAEMK IAIYLSKSGI CSLHPLLRGW EEALENVIKS TKPGKLIGVA 660
NQKMIELLAD NINLGDPSSM LKMVEDLISV GEEESFNLKQ KVTFHVILSV LVSCCSSLKE 720
THFPFAIRVF SLLQKKIKKL ESVITAVEIP SEWHIELMLD RGIPVELWAH YVEELNSTQR 780
VAVEDSVFLV FSLKKFIYAL KAPKSFPKGD IWWNPEQLKE DSRDYLHLLI GLFEMMLNGA 840
DAVHFRVLMK LFIKVHLEDV FQLFKFCSVL WTYGSSLSNP LNCSVKTVLQ TQALYVGCAM 900
LSSQKTQCKH QLASISSPVV TSLLINLGSP VKEVRRAAIQ CLQALSGVAS PFYLIIDHLI 960
SKAEEITSDA AYVIQDLATL FEELQREKKL KSHQKLSETL KNLLSCVYSC PSYIAKDLMK 1020
VLQGVNGEIT KPFFAAISDE KVQQKLLRML FDLLVNCKNS HCAQTVSSVF KGISVNAEQV 1080
RIELEPPDKA KPLGTVQQKR RQKMQQKKSQ DLESVQEVGG SYWQRVTLIL ELLQHKKKLR 1140
SPQILVPTLF NLLSRCLEPL PQEQGNMEYT KQLILSCLLN ICQKLSPDGG KIPKDILDEE 1200
KFNVELIVQC IRLSEMPQTH HHALLLLGTV AGIFPDKVLH NIMSIFTFMG ANVMRLDDTY 1260
SFQVINKTVK MVIPALIQSD SGDSIEVSRN VEEIVVKIIS VFVDALPHVP EHRRLPILVQ 1320
LVDTLGAEKF LWILLILLFE QYVTKTVLAA AYGEKDAILE ADTEFWFSVC CEFSVQHQIQ 1380
SLMNILQYLL KLPEEKEETI PKAVSFNKSE SQEEMLQVFN VETHTSKQLR HFKFLSVSFM 1440
SQLLSSNNFL KKVVESGGPE ILKGLEERLL ETVLGYISAV AQSMERNADK LTVKFWRALL 1500
SKAYDLLDKV NALLPTETFI PVIRGLVGNP LPSVRRKALD LLNNKLQQNI SWKKTIVTRF 1560
LKLVPDLLAI VQRKKKEGEE EQAINRQTAL YTLKLLCKNF GAENPDPFVP VLNTAVKLIA 1620
PERKEEKNVL GSALLCIAEV TSTLEALAIP QLPSLMPSLL TTMKNTSELV SSEVYLLSAL 1680
AALQKVVETL PHFISPYLEG ILSQVIHLEK ITSEMGSASQ ANIRLTSLKK TLATTLAPRV 1740
LLPAIKKTYK QIEKNWKNHM GPFMSILQEH IGVMKKEELT SHQSQLTAFF LEALDFRAQH 1800
SENDLEEVGK TENCIIDCLV AMVVKLSEVT FRPLFFKLFD WAKTEDAPKD RLLTFYNLAD 1860
CIAEKLKGLF TLFAGHLVKP FADTLNQVNI SKTDEAFFDS ENDPEKCCLL LQFILNCLYK 1920
IFLFDTQHFI SKERAEALMM PLVDQLENRL GGEEKFQERV TKHLIPCIAQ FSVAMADDSL 1980
WKPLNYQILL KTRDSSPKVR FAALITVLAL AEKLKENYIV LLPESIPFLA ELMEDECEEV 2040
EHQCQKTIQQ LETVLGEPLQ SYF 2063 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR012954; BP28_C_dom.
 IPR022125; U3snoRNP10. 
Pfam
 PF08146; BP28CT
 PF12397; U3snoRNP10 
SMART
 SM01036; BP28CT 
PROSITE
  
PRINTS