UniProt Accession

 NSR1_YEAST; P27476; D6VUT9 

Genbank Protein ID

 X57185; X85807; Z72944; Z72946; BK006941 

Genbank Nucleotide ID

 CAA40472.1; CAA59817.1; CAA97173.1; CAA97180.1; DAA08250.1 

Protein Name

 Nuclear localization sequence-binding protein 

Protein Synonyms/Alias

 p67 

Gene Name

 NSR1 

Gene Synonyms/Alias

 YGR159C; G7001 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
224	ENKSYAEKAIQEMQG	acetylation	[1]
323	SNMEDAKKALDALQG	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Involved in pre-rRNA processing. Specifically binds nuclear localization sequences. Candidate for a receptor at the nucleus that may be involved in both RNA and protein transport. Binds telomeric sequences of the type (TG[1-3])n in vitro. 

Sequence Annotation

 DOMAIN 168 246 RRM 1.
 DOMAIN 267 345 RRM 2.
 REGION 353 384 RGG-box.
 REGION 366 384 RNA-binding RGG-box (By similarity).
 MOD_RES 353 353 Asymmetric dimethylarginine (Probable).
 MOD_RES 362 362 Asymmetric dimethylarginine (Probable).
 MOD_RES 366 366 Asymmetric dimethylarginine (Probable).
 MOD_RES 375 375 Asymmetric dimethylarginine (Probable).
 MOD_RES 379 379 Asymmetric dimethylarginine (Probable).
 MOD_RES 382 382 Asymmetric dimethylarginine (Probable).  

Keyword

 Complete proteome; DNA-binding; Methylation; Nucleus; Reference proteome; Repeat; RNA-binding; rRNA processing; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IDA:SGD.
 GO:0003697; F:single-stranded DNA binding; IDA:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0000028; P:ribosomal small subunit assembly; TAS:SGD.
 GO:0006364; P:rRNA processing; TAS:SGD. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS