CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042371
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase SIK3 
Protein Synonyms/Alias
  
Gene Name
 SIK3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
68EIDRTIGKGNFAVVKubiquitination[1]
273RARVLSGKFRIPFFMubiquitination[1]
309MEQICKHKWMKLGDAubiquitination[1]
312ICKHKWMKLGDADPNubiquitination[1]
331IAECQQLKEERQVDPubiquitination[1]
678AASIQAFKAHLEKMGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1363 AA 
Protein Sequence
XGAGGAAGAG TGGAGPAGRL LPPPAPGSPA APAAVSPAAG QPRPPAPASR GPMPARIGYY 60
EIDRTIGKGN FAVVKRATHL VTKAKVAIKI IDKTQLDEEN LKKIFREVQI MKMLCHPHII 120
RLYQVMETER MIYLVTEYAS GGEIFDHLVA HGRMAEKEAR RKFKQIVTAV YFCHCRNIVH 180
RDLKAENLLL DANLNIKIAD FGFSNLFTPG QLLKTWCGSP PYAAPELFEG KEYDGPKVDI 240
WSLGVVLYVL VCGALPFDGS TLQNLRARVL SGKFRIPFFM STECEHLIRH MLVLDPNKRL 300
SMEQICKHKW MKLGDADPNF DRLIAECQQL KEERQVDPLN EDVLLAMEDM GLDKEQTLQS 360
LRSDAYDHYS AIYSLLCDRH KRHKTLRLGA LPSMPRALAF QAPVNIQAEQ AGTAMNISVP 420
QVQLINPENQ IVEPDGTLNL DSDEGEEPSP EALVRYLSMR RHTVGVADPR TEVMEDLQKL 480
LPGFPGVNPQ APFLQVAPNV NFMHNLLPMQ NLQPTGQLEY KEQSLLQPPT LQLLNGMGPL 540
GRRASDGGAN IQLHAQQLLK RPRGPSPLVT MTPAVPAVTP VDEESSDGEP DQEAVQRYLA 600
NRSKRHTLAM TNPTAEIPPD LQRQLGQQPF RSRVWPPHLV PDQHRSTYKD SNTLHLPTER 660
FSPVRRFSDG AASIQAFKAH LEKMGNNSSI KQLQQECEQL QKMYGGQIDE RTLEKTQQQH 720
MLYQQEQHHQ ILQQQIQDSI CPPQPSPPLQ AACENQPALL THQLQRLRIQ PSSPPPNHPN 780
NHLFRQPSNS PPPMSSAMIQ PHGAASSSQF QGLPSRSAIF QQQPENCSSP PNVALTCLGM 840
QQPAQSQQVT IQVQEPVDML SNMPGTAAGS SGRGISISPS AGQMQMQHRT NLMATLSYGH 900
RPLSKQLSAD SAEAHSLNVN RFSPANYDQA HLHPHLFSDQ SRGSPSSYSP STGVGFSPTQ 960
ALKVPPLDQF PTFPPSAHQQ PPHYTTSALQ QALLSPTPPD YTRHQQVPHI LQGLLSPRHS 1020
LTGHSDIRLP PTEFAQLIKR QQQQRQQQQQ QQQQQEYQEL FRHMNQGDAG SLAPSLGGQS 1080
MTERQALSYQ NADSYHHHTS PQHLLQIRAQ ECVSQASSPT PPHGYAHQPA LMHSESMEED 1140
CSCEGAKDGF QDSKSSSTLT KGCHDSPLLL STGGPGDPES LLGTVSHAQE LGIHPYGHQP 1200
TAAFSKNKVP SREPVIGNCM DRSSPGQAVE LPDHNGLGYP ARPSVHEHHR PRALQRHHTI 1260
QNSDDAYVQL DNLPGMSLVA GKALSSARMS DAVLSQSSLM GSQQFQDGEN EECGASLGGH 1320
EHPDLSDGSQ HLNSSCYPST CITDILLSYK HPEVSFSMEQ AGV 1363 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR015940; UBA/transl_elong_EF1B_N_euk. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50030; UBA 
PRINTS