UniProt Accession

 B7Z6Q6_HUMAN; B7Z6Q6 

Genbank Protein ID

 AL592166; AK300756 

Genbank Nucleotide ID

 BAH13342.1 

Protein Name

 Kinesin-like protein KIF2C 

Protein Synonyms/Alias

 cDNA FLJ54088, highly similar to Kinesin-like protein KIF2C 

Gene Name

 KIF2C 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	LFPGLAIKIQRSNGL	ubiquitination	[1]
52	WAEGGATKGKEIDFD	ubiquitination	[2]
54	EGGATKGKEIDFDDV	ubiquitination	[2]
90	QENVTIQKQKRRSVN	ubiquitination	[1, 2, 3]
92	NVTIQKQKRRSVNSK	ubiquitination	[1]
99	KRRSVNSKIPAPKES	ubiquitination	[1]
104	NSKIPAPKESLRSRS	ubiquitination	[1, 2]
155	RRKSCLVKEVEKMKN	acetylation	[4]
155	RRKSCLVKEVEKMKN	ubiquitination	[2]
245	DVISIPSKCLLLVHE	ubiquitination	[1, 2]
254	LLLVHEPKLKVDLTK	ubiquitination	[2]
256	LVHEPKLKVDLTKYL	ubiquitination	[1, 2]
300	QTIFEGGKATCFAYG	ubiquitination	[2]
313	YGQTGSGKTHTMGGD	ubiquitination	[2]
324	MGGDLSGKAQNASKG	ubiquitination	[1, 2, 3, 5, 6]
330	GKAQNASKGIYAMAS	ubiquitination	[1, 2]
344	SRDVFLLKNQPCYRK	ubiquitination	[2]
374	KLFDLLNKKAKLRVL	ubiquitination	[3]
375	LFDLLNKKAKLRVLE	ubiquitination	[2]
385	LRVLEDGKQQVQVVG	ubiquitination	[2, 3]
446	AKGRMHGKFSLVDLA	ubiquitination	[2]
477	MEGAEINKSLLALKE	ubiquitination	[2, 7]
483	NKSLLALKECIRALG	ubiquitination	[2]
493	IRALGQNKAHTPFRE	ubiquitination	[1, 2]
502	HTPFRESKLTQVLRD	ubiquitination	[1, 2]
651	SALAQQAKHFSALRD	ubiquitination	[1, 2, 5]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Microtubule; Motor protein; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 684 AA 

Protein Sequence

Gene Ontology

 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 

Interpro

 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00225; Kinesin 

SMART

 SM00129; KISc 

PROSITE

 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 

PRINTS

 PR00380; KINESINHEAVY.