UniProt Accession

 B9D1_HUMAN; Q9UPM9; Q9BU22 

Genbank Protein ID

 AB030506; BC002944 

Genbank Nucleotide ID

 BAA82655.1; AAH02944.1 

Protein Name

 B9 domain-containing protein 1 

Protein Synonyms/Alias

 MKS1-related protein 1 

Gene Name

 B9D1 

Gene Synonyms/Alias

 MKSR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
129	FVPESTSKLQKFTSW	ubiquitination	[1]
132	ESTSKLQKFTSWFMG	ubiquitination	[2, 3, 4]
180	VVTKDMRKLGYDTGP	ubiquitination	[2, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). 

Sequence Annotation

 DOMAIN 9 127 B9.  

Keyword

 Alternative splicing; Cell projection; Ciliopathy; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Meckel syndrome; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.
 GO:0005932; C:microtubule basal body; IDA:UniProtKB.
 GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
 GO:0008158; F:hedgehog receptor activity; ISS:UniProtKB.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB. 

Interpro

 IPR010796; B9_dom. 

Pfam

 PF07162; B9-C2 

SMART

  

PROSITE

 PS51381; B9 

PRINTS