UniProt Accession

 SPB5_HUMAN; P36952; B2R6Y4; Q6N0B4; Q8WW89 

Genbank Protein ID

 U04313; AK312765; AC036176; BC020713; BX640597 

Genbank Nucleotide ID

 AAA18957.1; BAG35631.1; AAH20713.1; CAE45703.1 

Protein Name

 Serpin B5 

Protein Synonyms/Alias

 Maspin; Peptidase inhibitor 5; PI-5 

Gene Name

 SERPINB5 

Gene Synonyms/Alias

 PI5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
277	KLSIPKFKVEKMIDP	acetylation	[1]
280	IPKFKVEKMIDPKAC	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. 

Sequence Annotation

 CARBOHYD 99 99 N-linked (GlcNAc...) (Potential).
 CARBOHYD 133 133 N-linked (GlcNAc...) (Potential).
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
 CARBOHYD 361 361 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Glycoprotein; Polymorphism; Reference proteome; Secreted. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0006928; P:cellular component movement; TAS:ProtInc.
 GO:0030198; P:extracellular matrix organization; IEA:Compara.
 GO:0002009; P:morphogenesis of an epithelium; IEA:Compara.
 GO:0060512; P:prostate gland morphogenesis; IEA:Compara.
 GO:0050678; P:regulation of epithelial cell proliferation; IEA:Compara.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome. 

Interpro

 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR000240; Serpin_B9/Maspin.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 

Pfam

 PF00079; Serpin 

SMART

 SM00093; SERPIN 

PROSITE

 PS00284; SERPIN 

PRINTS

 PR00676; MASPIN.