| Tag | Content |
|---|
| CPLM ID | CPLM-005570 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tetraacyldisaccharide 4'-kinase |
Protein Synonyms/Alias | Lipid A 4'-kinase |
Gene Name | lpxK |
Gene Synonyms/Alias | ycaH; b0915; JW0898 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 189 | RERAGRLKSVDAVIV | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). |
Sequence Annotation | NP_BIND 55 62 ATP (Potential). |
Keyword | ATP-binding; Complete proteome; Kinase; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; Nucleotide-binding; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 328 AA |
Protein Sequence | MIEKIWSGES PLWRLLLPLS WLYGLVSGAI RLCYKLKLKR AWRAPVPVVV VGNLTAGGNG 60
KTPVVVWLVE QLQQRGIRVG VVSRGYGGKA ESYPLLLSAD TTTAQAGDEP VLIYQRTDAP 120
VAVSPVRSDA VKAILAQHPD VQIIVTDDGL QHYRLARDVE IVVIDGVRRF GNGWWLPAGP 180
MRERAGRLKS VDAVIVNGGV PRSGEIPMHL LPGQAVNLRT GTRCDVAQLE HVVAMAGIGH 240
PPRFFATLKM CGVQPEKCVP LADHQSLNHA DVSALVSAGQ TLVMTEKDAV KCRAFAEENW 300
WYLPVDAQLS GDEPAKLLTQ LTLLASGN 328 |
Gene Ontology | GO:0016020; C:membrane; IDA:EcoliWiki. GO:0005524; F:ATP binding; IEA:HAMAP. GO:0009029; F:tetraacyldisaccharide 4'-kinase activity; IDA:EcoliWiki. GO:0009245; P:lipid A biosynthetic process; IDA:EcoliWiki. GO:0009244; P:lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |