UniProt Accession

 COIA1_HUMAN; P39060; A8MVI4; Q58EX6; Q6RZ39; Q6RZ40; Q6RZ41; Q8N4S4; Q8WXI5; Q96T70; Q9UK38; Q9Y6Q7; Q9Y6Q8 

Genbank Protein ID

 AF018081; AF018082; AY484971; AY484968; AY484969; AY484970; AY484971; AY484968; AY484969; AY484970; AY484971; AY484967; AY484969; AY484970; AL163302; BX322561; BC033715; BC063833; L22548; AF416592; AF184060; AF333247 

Genbank Nucleotide ID

 AAC39658.1; AAC39659.1; AAR83296.1; AAR83296.1; AAR83296.1; AAR83296.1; AAR83297.1; AAR83297.1; AAR83297.1; AAR83297.1; AAR83298.1; AAR83298.1; AAR83298.1; AAR83298.1; CAB90482.1; AAH33715.1; AAH63833.1; AAA51864.1; AAL37720.1; AAF01310.1; AAK50626.1 

Protein Name

 Collagen alpha-1(XVIII) chain 

Protein Synonyms/Alias

 Endostatin 

Gene Name

 COL18A1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
1677	RIFSFDGKDVLRHPT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. 

Sequence Annotation

 DOMAIN 329 446 FZ.
 DOMAIN 456 644 Laminin G-like.
 REGION 645 751 Nonhelical region 1 (NC1).
 REGION 752 785 Triple-helical region 1 (COL1).
 REGION 786 795 Nonhelical region 2 (NC2).
 REGION 796 875 Triple-helical region 2 (COL2).
 REGION 876 899 Nonhelical region 3 (NC3).
 REGION 900 1021 Triple-helical region 3 (COL3).
 REGION 1022 1044 Nonhelical region 4 (NC4).
 REGION 1045 1127 Triple-helical region 4 (COL4).
 REGION 1128 1141 Nonhelical region 5 (NC5).
 REGION 1142 1183 Triple-helical region 5 (COL5).
 REGION 1184 1196 Nonhelical region 6 (NC6).
 REGION 1197 1269 Triple-helical region 6 (COL6).
 REGION 1270 1279 Nonhelical region 7 (NC7).
 REGION 1280 1312 Triple-helical region 7 (COL7).
 REGION 1313 1324 Nonhelical region 8 (NC8).
 REGION 1325 1346 Triple-helical region 8 (COL8).
 REGION 1347 1353 Nonhelical region 9 (NC9).
 REGION 1354 1411 Triple-helical region 9 (COL9).
 REGION 1412 1424 Nonhelical region 10 (NC10).
 REGION 1425 1442 Triple-helical region 10 (COL10).
 REGION 1443 1754 Nonhelical region 11 (NC11).
 MOTIF 1330 1332 Cell attachment site (Potential).
 METAL 1572 1572 Zinc.
 METAL 1574 1574 Zinc.
 METAL 1582 1582 Zinc.
 METAL 1647 1647 Zinc.
 CARBOHYD 68 68 N-linked (GlcNAc...) (Potential).
 CARBOHYD 129 129 N-linked (GlcNAc...) (Potential).
 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 CARBOHYD 926 926 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1567 1567 O-linked (GalNAc...).
 DISULFID 334 397 By similarity.
 DISULFID 344 390 By similarity.
 DISULFID 381 419 By similarity.
 DISULFID 408 443 By similarity.
 DISULFID 412 432 By similarity.
 DISULFID 1604 1744 By similarity.
 DISULFID 1706 1736 By similarity.  

Keyword

 3D-structure; Alternative promoter usage; Alternative splicing; Cell adhesion; Collagen; Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; Hydroxylation; Metal-binding; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1754 AA 

Protein Sequence

Gene Ontology

 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0005581; C:collagen; TAS:ProtInc.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0030574; P:collagen catabolic process; TAS:Reactome.
 GO:0001886; P:endothelial cell morphogenesis; IEA:Compara.
 GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0009887; P:organ morphogenesis; TAS:ProtInc.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR026917; COL18A1.
 IPR008160; Collagen.
 IPR010515; Collagenase_NC10/endostatin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR010363; DUF959_COL18_N.
 IPR020067; Frizzled_dom.
 IPR001791; Laminin_G. 

Pfam

 PF01391; Collagen
 PF06121; DUF959
 PF06482; Endostatin
 PF01392; Fz 

SMART

 SM00063; FRI
 SM00282; LamG
 SM00210; TSPN 

PROSITE

 PS50038; FZ
 PS50025; LAM_G_DOMAIN 

PRINTS