UniProt Accession

 RALB_HUMAN; P11234; Q53T32 

Genbank Protein ID

 X15015; M35416; AF493911; BT006953; AK312453; AC012363; CH471103; BC018163 

Genbank Nucleotide ID

 CAA33119.1; AAA60250.1; AAM12625.1; AAP35599.1; BAG35360.1; AAY14800.1; EAW95240.1; AAH18163.1 

Protein Name

 Ras-related protein Ral-B 

Protein Synonyms/Alias

  

Gene Name

 RALB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	KADSYRKKVVLDGEE	ubiquitination	[1]

Reference

 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. 

Sequence Annotation

 NP_BIND 21 29 GTP.
 NP_BIND 68 72 GTP.
 NP_BIND 128 131 GTP.
 NP_BIND 158 160 GTP.
 MOTIF 43 51 Effector region (By similarity).
 MOD_RES 203 203 Cysteine methyl ester.
 LIPID 203 203 S-geranylgeranyl cysteine.  

Keyword

 3D-structure; Apoptosis; Cell cycle; Cell division; Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0000910; P:cytokinesis; IDA:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0007265; P:Ras protein signal transduction; TAS:Reactome.
 GO:0001928; P:regulation of exocyst assembly; ISS:UniProtKB.
 GO:0060178; P:regulation of exocyst localization; ISS:UniProtKB. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.