CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008150
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 
Protein Synonyms/Alias
 PDHE1-B 
Gene Name
 Pdhb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
52EELERDEKVFLLGEEacetylation[1]
184PWNSEDAKGLIKSAIacetylation[1]
227DFLIPIGKAKIERQGacetylation[1]
336DVPMPYAKILEDNSIacetylation[1]
347DNSIPQVKDIIFAIKacetylation[1]
354KDIIFAIKKTLNI**acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle (By similarity). 
Sequence Annotation
 BINDING 89 89 Thiamine pyrophosphate (By similarity).
 MOD_RES 67 67 Phosphotyrosine (By similarity).  
Keyword
 Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Glucose metabolism; Mitochondrion; Oxidoreductase; Phosphoprotein; Pyruvate; Reference proteome; Thiamine pyrophosphate; Transit peptide; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MAAVAGLVRG PLRQASGLLK RRFHRSAPAA VQLTVREAIN QGMDEELERD EKVFLLGEEV 60
AQYDGAYKVS RGLWKKYGDK RIIDTPISEM GFAGIAVGAA MAGLRPICEF MTFNFSMQAI 120
DQVINSAAKT YYMSAGLQPV PIVFRGPNGA SAGVAAQHSQ CFAAWYGHCP GLKVVSPWNS 180
EDAKGLIKSA IRDDNPVVML ENELMYGVAF ELPTEAQSKD FLIPIGKAKI ERQGTHITVV 240
AHSRPVGHCL EAAAVLSKEG IECEVINLRT IRPMDIEAIE ASVMKTNHLV TVEGGWPQFG 300
VGAEICARIM EGPAFNFLDA PAVRVTGADV PMPYAKILED NSIPQVKDII FAIKKTLNI 359 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0045254; C:pyruvate dehydrogenase complex; IDA:RGD.
 GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IDA:RGD.
 GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IDA:RGD.
 GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
 GO:0006099; P:tricarboxylic acid cycle; ISS:UniProtKB. 
Interpro
 IPR027110; PDHB.
 IPR009014; Transketo_C/Pyr-ferredox_oxred.
 IPR015941; Transketolase-like_C.
 IPR005475; Transketolase-like_Pyr-bd.
 IPR005476; Transketolase_C. 
Pfam
 PF02779; Transket_pyr
 PF02780; Transketolase_C 
SMART
 SM00861; Transket_pyr 
PROSITE
  
PRINTS