UniProt Accession

 PSMD6_MOUSE; Q99JI4; Q9CWZ1 

Genbank Protein ID

 AJ252147; AK010287; BC006869 

Genbank Nucleotide ID

 CAC34579.1; BAB26823.1; AAH06869.1 

Protein Name

 26S proteasome non-ATPase regulatory subunit 6 

Protein Synonyms/Alias

 26S proteasome regulatory subunit RPN7; 26S proteasome regulatory subunit S10; p42A 

Gene Name

 Psmd6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	LEEEGLPKNPDLRIA	ubiquitination	[1]
117	YLCQIGDKEGALTAF	acetylation	[2]
130	AFRKTYDKTVALGHR	acetylation	[2]
284	IVEQEMKKDWLFAPH	acetylation	[2]
362	ETNRPDSKNWQYQET	ubiquitination	[1]
371	WQYQETIKKGDLLLN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. 

Sequence Annotation

 DOMAIN 191 358 PCI.  

Keyword

 Complete proteome; Proteasome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 389 AA 

Protein Sequence

Gene Ontology

 GO:0022624; C:proteasome accessory complex; IDA:UniProtKB. 

Interpro

 IPR019585; 26S_proteasome_reg_su-Rpn7.
 IPR000717; PCI_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01399; PCI
 PF10602; RPN7 

SMART

 SM00088; PINT 

PROSITE

  

PRINTS