UniProt Accession

 F5GWU0_HUMAN; F5GWU0 

Genbank Protein ID

 AC083829; AC098582; AC108065 

Genbank Nucleotide ID

  

Protein Name

 Probable E3 ubiquitin-protein ligase HERC3 

Protein Synonyms/Alias

  

Gene Name

 HERC3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
265	YKKLLNVKPGLEDLK	ubiquitination	[1, 2]
315	YGVIEQKKLIPGGDN	ubiquitination	[2]
364	FLKVCGGKVLELFQP	ubiquitination	[2, 3]
420	FHEFPLEKKKKFLLF	ubiquitination	[2]
474	DLPKYSSKEILSARL	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 494 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:GOC. 

Interpro

 IPR000569; HECT. 

Pfam

 PF00632; HECT 

SMART

 SM00119; HECTc 

PROSITE

 PS50237; HECT 

PRINTS