CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004485
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ferrochelatase, mitochondrial 
Protein Synonyms/Alias
 Heme synthase; Protoheme ferro-lyase 
Gene Name
 HEM15 
Gene Synonyms/Alias
 YOR176W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
81KYQKTIAKYIAKFRTacetylation[1]
130CPETAPHKPYVAFRYacetylation[1]
147PLTAETYKQMLKDGVacetylation[1]
381GKSNDPVKDLSLVFGacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Catalyzes the ferrous insertion into protoporphyrin IX. 
Sequence Annotation
 ACT_SITE 351 351 By similarity.  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Heme biosynthesis; Iron; Lyase; Membrane; Mitochondrion; Mitochondrion inner membrane; Porphyrin biosynthesis; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 393 AA 
Protein Sequence
MLSRTIRTQG SFLRRSQLTI TRSFSVTFNM QNAQKRSPTG IVLMNMGGPS KVEETYDFLY 60
QLFADNDLIP ISAKYQKTIA KYIAKFRTPK IEKQYREIGG GSPIRKWSEY QATEVCKILD 120
KTCPETAPHK PYVAFRYAKP LTAETYKQML KDGVKKAVAF SQYPHFSYST TGSSINELWR 180
QIKALDSERS ISWSVIDRWP TNEGLIKAFS ENITKKLQEF PQPVRDKVVL LFSAHSLPMD 240
VVNTGDAYPA EVAATVYNIM QKLKFKNPYR LVWQSQVGPK PWLGAQTAEI AEFLGPKVDG 300
LMFIPIAFTS DHIETLHEID LGVIGESEYK DKFKRCESLN GNQTFIEGMA DLVKSHLQSN 360
QLYSNQLPLD FALGKSNDPV KDLSLVFGNH EST 393 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
 GO:0004325; F:ferrochelatase activity; IDA:SGD.
 GO:0006783; P:heme biosynthetic process; IMP:SGD. 
Interpro
 IPR001015; Ferrochelatase.
 IPR019772; Ferrochelatase_AS. 
Pfam
 PF00762; Ferrochelatase 
SMART
  
PROSITE
 PS00534; FERROCHELATASE 
PRINTS