CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019467
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosomal protein of 63 kDa 
Protein Synonyms/Alias
 Cep63 
Gene Name
 CEP63 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55HALETCLKIREQELKubiquitination[1]
62KIREQELKSLRSQLDubiquitination[1]
73SQLDVTHKEVGMLHQubiquitination[1]
145EIERLTAKIEEFRQKubiquitination[1]
158QKSLDWEKQRLIYQQubiquitination[1]
175SSLEAQRKALAEQSEubiquitination[1]
260EKLRESEKLLEALQEubiquitination[1]
269LEALQEEKRELKAALubiquitination[1]
273QEEKRELKAALQSQEubiquitination[1]
298EKLQEKVKATNTQHAubiquitination[1]
350KAEIKKLKEQILQGEubiquitination[1]
389DITIASTKGSSSDMEubiquitination[1]
424LDQLESLKLENRHLSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Required for normal spindle assembly. Maintains centrosome numbers through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; DNA damage; Dwarfism; Mental retardation; Mitosis; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 703 AA 
Protein Sequence
MEALLEGIQN RGHGGGFLTS CEAELQELMK QIDIMVAHKK SEWEGRTHAL ETCLKIREQE 60
LKSLRSQLDV THKEVGMLHQ QVEEHEKIKQ EMTMEYKQEL KKLHEELCIL KRSYEKLQKK 120
QMREFRGNTK NHREDRSEIE RLTAKIEEFR QKSLDWEKQR LIYQQQVSSL EAQRKALAEQ 180
SEIIQAQLVN RKQKLESVEL SSQSEIQHLS SKLERANDTI CANELEIERL TMRVNDLVGT 240
SMTVLQEQQQ KEEKLRESEK LLEALQEEKR ELKAALQSQE NLIHEARIQK EKLQEKVKAT 300
NTQHAVEAIS LESVSATCKQ LSQELMEKYE ELKRMEAHNN EYKAEIKKLK EQILQGEQSY 360
SSALEGMKME ISHLTQELHQ RDITIASTKG SSSDMEKRLR AEMQKAEDKA VEHKEILDQL 420
ESLKLENRHL SEMVMKLELG LHECSLPVSP LGSIATRFLE EEELRSHHIL ERLDAHIEEL 480
KRESEKTVRQ FTALK 495 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000922; C:spindle pole; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000077; P:DNA damage checkpoint; ISS:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0042770; P:signal transduction in response to DNA damage; ISS:UniProtKB.
 GO:0051225; P:spindle assembly; ISS:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS