UniProt Accession

 TCAL1_HUMAN; Q15170; Q9UJQ9 

Genbank Protein ID

 M99701; AF095906; AL049610; BC000809 

Genbank Nucleotide ID

 AAA60149.1; AAD17840.1; CAB55700.1; AAH00809.1 

Protein Name

 Transcription elongation factor A protein-like 1 

Protein Synonyms/Alias

 TCEA-like protein 1; Nuclear phosphoprotein p21/SIIR; Transcription elongation factor S-II protein-like 1 

Gene Name

 TCEAL1 

Gene Synonyms/Alias

 SIIR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
136	ADELEEMKRVRNKLM	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly. 

Sequence Annotation

 MOD_RES 31 31 Phosphoserine.
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 36 36 Phosphoserine.
 MOD_RES 37 37 Phosphoserine.
 MOD_RES 41 41 Phosphoserine.
 MOD_RES 42 42 Phosphoserine.
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 48 48 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 157 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:ProtInc.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR021156; TF_A-like/BEX-like.
 IPR010370; TFA. 

Pfam

 PF04538; BEX 

SMART

  

PROSITE

  

PRINTS