CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001821
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive 
Protein Synonyms/Alias
 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase 
Gene Name
 aroF 
Gene Synonyms/Alias
 b2601; JW2582 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
98VMRVYFEKPRTTVGWacetylation[1]
187LSMPVGFKNGTDGSLacetylation[1]
274CSHGNSNKDYRRQPAacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). 
Sequence Annotation
  
Keyword
 Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Direct protein sequencing; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 356 AA 
Protein Sequence
MQKDALNNVH ITDEQVLMTP EQLKAAFPLS LQQEAQIADS RKSISDIIAG RDPRLLVVCG 60
PCSIHDPETA LEYARRFKAL AAEVSDSLYL VMRVYFEKPR TTVGWKGLIN DPHMDGSFDV 120
EAGLQIARKL LLELVNMGLP LATEALDPNS PQYLGDLFSW SAIGARTTES QTHREMASGL 180
SMPVGFKNGT DGSLATAINA MRAAAQPHRF VGINQAGQVA LLQTQGNPDG HVILRGGKAP 240
NYSPADVAQC EKEMEQAGLR PSLMVDCSHG NSNKDYRRQP AVAESVVAQI KDGNRSIIGL 300
MIESNIHEGN QSSEQPRSEM KYGVSVTDAC ISWEMTDALL REIHQDLNGQ LTARVA 356 
Gene Ontology
 GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:EC.
 GO:0009073; P:aromatic amino acid family biosynthetic process; IMP:EcoliWiki.
 GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR006218; DAHP1/KDSA.
 IPR006219; DHAP_synth_1. 
Pfam
 PF00793; DAHP_synth_1 
SMART
  
PROSITE
  
PRINTS