| Tag | Content |
|---|
| CPLM ID | CPLM-001080 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Fragile X mental retardation syndrome-related protein 1 |
Protein Synonyms/Alias | |
Gene Name | FXR1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) |
NCBI Taxa ID | 10029 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 246 | SNIQQARKVPGVTAI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). |
Sequence Annotation | DOMAIN 4 50 Agenet-like 1.
DOMAIN 63 115 Agenet-like 2.
DOMAIN 222 251 KH 1.
DOMAIN 285 314 KH 2.
REGION 442 457 RNA-binding RGG-box.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 68 68 Phosphotyrosine (By similarity).
MOD_RES 406 406 Phosphoserine (By similarity).
MOD_RES 409 409 Phosphoserine (By similarity).
MOD_RES 420 420 Phosphoserine (By similarity).
MOD_RES 423 423 Phosphoserine (By similarity).
MOD_RES 445 445 Omega-N-methylated arginine (By
MOD_RES 485 485 Phosphoserine (By similarity).
MOD_RES 585 585 Phosphoserine (By similarity).
MOD_RES 587 587 Phosphoserine (By similarity).
MOD_RES 611 611 Phosphothreonine (By similarity). |
Keyword | Acetylation; Cytoplasm; Developmental protein; Differentiation; Methylation; Myogenesis; Phosphoprotein; Repeat; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 621 AA |
Protein Sequence | MADVTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 60
EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 120
VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 180
VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 240
IQQARKVPGV TAIELDEDTG TFRIYGESAE AVKKARGFME FVEDFIQVPR NLVGKVIGKN 300
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 360
VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG TNSELSNPSE TESERKDELS 420
DWSLAGEDDR ETRHQRDSRR RPGGRGRSVS GGRGRGGPRG GKSSISSVLK DPDSNPYSLL 480
DNTESDQTAD TDASESHHST NRRRRSRRRR TDEDAVLMDG MTESDTASVN ENGLVTVADY 540
ISRAESQSRQ RNLPRETLAK NKKEMAKDVI EEHGPSEKAI NGPTSASGDE IPNVPRTPGE 600
EKTKNLKEES TQEAAVLNGV S 621 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0007517; P:muscle organ development; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |