CPLM-001259

Genbank Nucleotide ID

Protein Synonyms/Alias

ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ER-localized type I transmembrane adaptor; Embryonic liver differentiation factor 10; N14F; Renin/prorenin receptor; Vacuolar ATP synthase membrane sector-associated protein M8-9; ATP6M8-9; V-ATPase M8.9 subunit

ATP6IP2; CAPER; ELDF10; HT028; MSTP009; PSEC0072

Homo sapiens (Human)

Position	Peptide	Type	References
139	ERVYMVGKANSVFED	ubiquitination	[1, 2, 3]
205	SRHKHLAKDHSPDLY	ubiquitination	[1, 3]
224	AGLDEIGKRYGEDSE	ubiquitination	[1, 2, 3]
238	EQFRDASKILVDALQ	ubiquitination	[1, 2, 3, 4, 5, 6]
284	TRTILEAKQAKNPAS	ubiquitination	[1, 2]
346	IYRMTNQKIRMD***	ubiquitination	[1]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).

3D-structure; Complete proteome; Epilepsy; Membrane; Mental retardation; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0044297; C:cell body; IEA:Compara.
GO:0009897; C:external side of plasma membrane; IDA:HGNC.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0043005; C:neuron projection; IEA:Compara.
GO:0004190; F:aspartic-type endopeptidase activity; EXP:Reactome.
GO:0004872; F:receptor activity; IEA:InterPro.
GO:0002003; P:angiotensin maturation; IDA:HGNC.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0032914; P:positive regulation of transforming growth factor beta1 production; IDA:HGNC.
GO:0043408; P:regulation of MAPK cascade; IDA:HGNC.

IPR012493; Renin_rcpt.