UniProt Accession

 T2FB_DROME; P41900; Q9VGX4 

Genbank Protein ID

 U25188; U02461; AE014297; AY071514 

Genbank Nucleotide ID

 AAA86888.1; AAA81888.1; AAF54548.1; AAL49136.1 

Protein Name

 General transcription factor IIF subunit 2 

Protein Synonyms/Alias

 ATP-dependent helicase TfIIF-beta; Transcription initiation factor IIF subunit beta; TFIIF-beta 

Gene Name

 TfIIFbeta 

Gene Synonyms/Alias

 TFIIF30; CG6538 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
37	VPKYIAQKWEKAPTN	acetylation	[1]
171	DKIVQNFKPVKDHAH	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA- helicase activity (By similarity). 

Sequence Annotation

 NP_BIND 43 50 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0005674; C:transcription factor TFIIF complex; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IDA:FlyBase.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:FlyBase.
 GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IDA:FlyBase.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISS:FlyBase. 

Interpro

 IPR016640; TFIIF-beta_subgr.
 IPR003196; TFIIF_beta.
 IPR011039; TFIIF_interaction.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF02270; TFIIF_beta 

SMART

  

PROSITE

  

PRINTS