| Tag | Content |
|---|
| CPLM ID | CPLM-020970 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase synoviolin |
Protein Synonyms/Alias | Synovial apoptosis inhibitor 1 |
Gene Name | Syvn1 |
Gene Synonyms/Alias | Hrd1; Kiaa1810 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 257 | LAMRQFKKAVTDAIM | ubiquitination | [1] | | 605 | LRRRRLQKLESPVAH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Required for embryogenesis. |
Sequence Annotation | ZN_FING 291 330 RING-type; atypical.
REGION 236 270 Interaction with p53/TP53.
MOD_RES 608 608 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Developmental protein; Endoplasmic reticulum; Ligase; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 612 AA |
Protein Sequence | MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA FVLVFLLGKV 60
MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS PRFVALFTLL LFLKCFHWLA 120
EDRVDFMERS PNISWLFHCR IVSLMFLLGI LDFLFVSHAY HSILTRGASV QLVFGFEYAI 180
LMTMVLTIFI KYVLHSVDLQ SENPWDNKAV YMLYTELFTG FIKVLLYMAF MTIMIKVHTF 240
PLFAIRPMYL AMRQFKKAVT DAIMSRRAIR NMNTLYPDAT PEELQAVDNV CIICREEMVT 300
GAKRLPCNHI FHTSCLRSWF QRQQTCPTCR MDVLRASLPA QSPPPPEPAD QGPPPAPHPQ 360
PLLPQPPNFP QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS GEAAAPPPTS TAVSRPSGAA 420
TTTAAGTSTS APAPGSVPGP EAGPAPGFPF PPPWMGMPLP PPFAFPPMPV PPAGFAGLTP 480
EELRALEGHE RQHLEARLQS LRNIHTLLDA AMLQINQYLT VLASLGPPRP ATSVNPTEET 540
ASTVVSAAPS TSAPSSEAPT PSPGASPPIP EAEKPPAPES VGIVEELPED GEPDAAELRR 600
RRLQKLESPV AH 612 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; ISO:MGI. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:Compara. GO:0000151; C:ubiquitin ligase complex; ISO:MGI. GO:0004842; F:ubiquitin-protein ligase activity; ISO:MGI. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0030433; P:ER-associated protein catabolic process; ISS:UniProtKB. GO:0001701; P:in utero embryonic development; IMP:MGI. GO:0043066; P:negative regulation of apoptotic process; IMP:MGI. GO:0018279; P:protein N-linked glycosylation via asparagine; ISS:UniProtKB. GO:0006986; P:response to unfolded protein; ISO:MGI. |
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