CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025956
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Copine-1 
Protein Synonyms/Alias
  
Gene Name
 CPNE1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
133TITDFLGKSDPFLEFubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 386 AA 
Protein Sequence
MAHCVTLVQL SISCDHLIDK DIGSKSDPLC VLLQDVGGGS WAELGRTERV RNCSSPEFSK 60
TLQLEYRFET VQKLRFGIYD IDNKTPELRD DDFLGGAECS LGQIVSSQVL TLPLMLKPGK 120
PAGRGTITDF LGKSDPFLEF FRQGDGKWHL VYRSEVIKNN LNPTWKRFSV PVQHFCGGNP 180
STPIQVQCSD YDSDGSHDLI GTFHTSLAQL QAVPAEFECI HPEKQQKKKS YKNSGTIRVK 240
ICRVETEYSF LDYVMGGCQI NFTVGVDFTG SNGDPSSPDS LHYLSPTGVN EYLMALWSVG 300
SVVQDYDSDK LFPAFGFGAQ VPPDWQVSHE FALNFNPSNP YCAGIQGIVD AYRQALPQVR 360
LYGPTNFAPI INHVARFAAQ AAHQGT 386 
Gene Ontology
  
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR010734; Copine. 
Pfam
 PF00168; C2
 PF07002; Copine 
SMART
 SM00239; C2 
PROSITE
  
PRINTS