UniProt Accession

 ORC6_HUMAN; Q9Y5N6; B3KN89 

Genbank Protein ID

 AF139658; AK024019; CH471092; BC039032; BC063565 

Genbank Nucleotide ID

 AAD32666.1; BAG51251.1; EAW82685.1; AAH39032.1; AAH63565.1 

Protein Name

 Origin recognition complex subunit 6 

Protein Synonyms/Alias

  

Gene Name

 ORC6 

Gene Synonyms/Alias

 ORC6L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	AEPDMLRKAEEYLRL	ubiquitination	[1]
34	YLRLSRVKCVGLSAR	ubiquitination	[1]
70	LDRAYLIKLSGLNKE	ubiquitination	[1]
76	IKLSGLNKETYQSCL	ubiquitination	[1]
119	NMASKILKSYESSLP	ubiquitination	[1]
177	AIFDRLCKQLEKIGQ	ubiquitination	[1]
238	DYEEWKRKILENAAS	ubiquitination	[1]
248	ENAASAQKATAE***	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. 

Sequence Annotation

 MOD_RES 195 195 Phosphothreonine.
 MOD_RES 229 229 Phosphothreonine.  

Keyword

 3D-structure; Complete proteome; Disease mutation; DNA replication; DNA-binding; Dwarfism; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0005664; C:nuclear origin of replication recognition complex; IEA:InterPro.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0000808; C:origin recognition complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; TAS:Reactome.
 GO:0006261; P:DNA-dependent DNA replication; IEA:Compara.
 GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome. 

Interpro

 IPR008721; ORC6.
 IPR020529; ORC6_met/pln. 

Pfam

 PF05460; ORC6 

SMART

  

PROSITE

  

PRINTS