| Tag | Content |
|---|
| CPLM ID | CPLM-022774 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tripartite motif-containing protein 3 |
Protein Synonyms/Alias | RING finger protein 22; RING finger protein HAC1 |
Gene Name | Trim3 |
Gene Synonyms/Alias | Hac1; Rnf22 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 565 | SIFSPEGKFKTKIGA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). |
Sequence Annotation | REPEAT 317 418 Filamin.
REPEAT 473 516 NHL 1.
REPEAT 520 563 NHL 2.
REPEAT 564 605 NHL 3.
REPEAT 609 652 NHL 4.
REPEAT 656 699 NHL 5.
REPEAT 700 743 NHL 6.
ZN_FING 22 63 RING-type.
ZN_FING 110 151 B box-type.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 7 7 Phosphoserine. |
Keyword | Acetylation; Coiled coil; Complete proteome; Cytoplasm; Endosome; Metal-binding; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 744 AA |
Protein Sequence | MAKREDSPGP EVQPMDKQFL VCSICLDRYR CPKVLPCLHT FCERCLQNYI PPQSLTLSCP 60
VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPEGAHDPE DPHPLSAVAG RPLSCPNHEG 120
KTMEFYCEAC ETAMCGECRA GEHREHGTVL LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI 180
ALVGGISQQL QERKAEALAQ ISAAFEDLEQ ALQQRKQALV SDLESICGAK QKVLQTQLDT 240
LRQGQEHIGS SCSFAEQALR LGSAPEVLLV RKHMRERLAA LAAQAFPERP HENAQLELVL 300
EVDGLRRSVL NLGALLTTSA TAHETVATGE GLRQALVGQP ASLTVTTKDK DGRLVRTGSA 360
ELCAEITGPD GVRLAVPVVD HKNGTYELVY TARTEGDLLL SVLLYGQPVR GSPFRVRALR 420
PGDLPPSPDD VKRRVKSPGG PGSHVRQKAV RRPSSMYSTG GKRKDNPIED ELVFRVGSRG 480
REKGEFTNLQ GVSAASSGRI VVADSNNQCI QVFSNEGQFK FRFGVRGRSP GQLQRPTGVA 540
VDTNGDIIVA DYDNRWVSIF SPEGKFKTKI GAGRLMGPKG VAVDRNGHII VVDNKSCCVF 600
TFQPNGKLVG RFGGRGATDR HFAGPHFVAV NNKNEIVVTD FHNHSVKVYS ADGEFLFKFG 660
SHGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDSSG SFLSYINTSA EPLYGPQGLA 720
LTSDGHVVVA DAGNHCFKAY RYLQ 744 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |