CPLM-009682

Genbank Nucleotide ID

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Protein Synonyms/Alias

Adenylate cyclase-stimulating G alpha protein

Homo sapiens (Human)

Position	Peptide	Type	References
8	MGCLGNSKTEDQRNE	ubiquitination	[1]
53	LGAGESGKSTIVKQM	ubiquitination	[1]
58	SGKSTIVKQMRILHV	ubiquitination	[1]
73	NGFNGDEKATKVQDI	ubiquitination	[1]
76	NGDEKATKVQDIKNN	ubiquitination	[1]
81	ATKVQDIKNNLKEAI	ubiquitination	[1]
171	LDKIDVIKQADYVPS	ubiquitination	[1]
201	ETKFQVDKVNFHMFD	ubiquitination	[1]
259	QEALNLFKSIWNNRW	ubiquitination	[1]
285	KQDLLAEKVLAGKSK	ubiquitination	[1]
290	AEKVLAGKSKIEDYF	ubiquitination	[1]
292	KVLAGKSKIEDYFPE	ubiquitination	[1]
323	DPRVTRAKYFIRDEF	ubiquitination	[1]

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli.

NP_BIND 47 54 GTP (By similarity).
NP_BIND 198 204 GTP (By similarity).
NP_BIND 223 227 GTP (By similarity).
NP_BIND 292 295 GTP (By similarity).
METAL 54 54 Magnesium (By similarity).
METAL 204 204 Magnesium (By similarity).
BINDING 366 366 GTP; via amide nitrogen (By similarity).
MOD_RES 51 51 Phosphoserine (By similarity).
MOD_RES 201 201 ADP-ribosylarginine; by cholera toxin (By
MOD_RES 352 352 Phosphoserine.
LIPID 2 2 N-palmitoyl glycine (By similarity).
LIPID 3 3 S-palmitoyl cysteine.
CROSSLNK 300 300 Glycyl lysine isopeptide (Lys-Gly)

ADP-ribosylation; Alternative splicing; Cell membrane; Complete proteome; Cushing syndrome; Direct protein sequencing; Disease mutation; GTP-binding; Isopeptide bond; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Transducer; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005737; C:cytoplasm; IDA:LIFEdb.
GO:0005834; C:heterotrimeric G-protein complex; TAS:UniProtKB.
GO:0031224; C:intrinsic to membrane; IDA:UniProtKB.
GO:0032588; C:trans-Golgi network membrane; IDA:UniProtKB.
GO:0004016; F:adenylate cyclase activity; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0003924; F:GTPase activity; TAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
GO:0007190; P:activation of adenylate cyclase activity; TAS:UniProtKB.
GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; ISS:BHF-UCL.
GO:0007596; P:blood coagulation; TAS:Reactome.
GO:0071870; P:cellular response to catecholamine stimulus; ISS:BHF-UCL.
GO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome.
GO:0071380; P:cellular response to prostaglandin E stimulus; ISS:BHF-UCL.
GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
GO:0046907; P:intracellular transport; NAS:UniProtKB.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0007608; P:sensory perception of smell; TAS:UniProtKB.
GO:0055085; P:transmembrane transport; TAS:Reactome.
GO:0006833; P:water transport; TAS:Reactome.

IPR000367; Gprotein_alpha_S.
IPR001019; Gprotein_alpha_su.
IPR011025; GproteinA_insert.
IPR027417; P-loop_NTPase.

PR00318; GPROTEINA.
PR00443; GPROTEINAS.