UniProt Accession

 SEP11_MOUSE; Q8C1B7; Q3TBA0; Q3TC24; Q5D0F0; Q6P2K5; Q6P6I0 

Genbank Protein ID

 AK028475; AK166517; AK170945; AK171368; BC031456; BC062206; BC064466 

Genbank Nucleotide ID

 BAC25969.1; BAE38822.1; BAE42133.1; BAE42414.1; AAH31456.1; AAH62206.1; AAH64466.1 

Protein Name

 Septin-11 

Protein Synonyms/Alias

  

Gene Name

 Sept11 

Gene Synonyms/Alias

 D5Ertd606e 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
184	NIIPIIAKADTIAKN	acetylation	[1]
190	AKADTIAKNELHKFK	acetylation	[1]
326	LQETYEAKRNEFLGE	ubiquitination	[2]
336	EFLGELQKKEEEMRQ	ubiquitination	[2]
366	AEKELHEKFDLLKRT	acetylation	[3]
397	EEVSNFQKKKAAAQL	acetylation	[1, 3]
397	EEVSNFQKKKAAAQL	ubiquitination	[2]
399	VSNFQKKKAAAQLLQ	ubiquitination	[2]
418	QSGAQQTKKDKDKKN	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). 

Sequence Annotation

 NP_BIND 48 55 GTP (By similarity).
 NP_BIND 184 192 GTP (By similarity).
 BINDING 103 103 GTP; via amide nitrogen (By similarity).
 BINDING 238 238 GTP; via amide nitrogen and carbonyl
 BINDING 253 253 GTP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Cell cycle; Cell division; Cell junction; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Nucleotide-binding; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 431 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051291; P:protein heterooligomerization; IEA:Compara. 

Interpro

 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 

Pfam

 PF00735; Septin 

SMART

  

PROSITE

  

PRINTS