CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002461
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome b-c1 complex subunit 1, mitochondrial 
Protein Synonyms/Alias
 Complex III subunit 1; Core protein I; Ubiquinol-cytochrome-c reductase complex core protein 1 
Gene Name
 COR1 
Gene Synonyms/Alias
 QCR1; YBL045C; YBL0403 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
80WKNIFLSKENSAVAAacetylation[1]
146ATKKSVLKQVQDFEEacetylation[1]
408LSLGEAFKKIDAITVacetylation[1]
416KIDAITVKDVKAWAGacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919
Functional Description
 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. COR1 may mediate formation of the complex between cytochromes c and c1. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Respiratory chain; Transit peptide; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 457 AA 
Protein Sequence
MLRTVTSKTV SNQFKRSLAT AVATPKAEVT QLSNGIVVAT EHNPSAHTAS VGVVFGSGAA 60
NENPYNNGVS NLWKNIFLSK ENSAVAAKEG LALSSNISRD FQSYIVSSLP GSTDKSLDFL 120
NQSFIQQKAN LLSSSNFEAT KKSVLKQVQD FEENDHPNRV LEHLHSTAFQ NTPLSLPTRG 180
TLESLENLVV ADLESFANNH FLNSNAVVVG TGNIKHEDLV NSIESKNLSL QTGTKPVLKK 240
KAAFLGSEVR LRDDTLPKAW ISLAVEGEPV NSPNYFVAKL AAQIFGSYNA FEPASRLQGI 300
KLLDNIQEYQ LCDNFNHFSL SYKDSGLWGF STATRNVTMI DDLIHFTLKQ WNRLTISVTD 360
TEVERAKSLL KLQLGQLYES GNPVNDANLL GAEVLIKGSK LSLGEAFKKI DAITVKDVKA 420
WAGKRLWDQD IAIAGTGQIE GLLDYMRIRS DMSMMRW 457 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005750; C:mitochondrial respiratory chain complex III; IDA:SGD.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0009060; P:aerobic respiration; IMP:SGD.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 
Interpro
 IPR011249; Metalloenz_LuxS/M16.
 IPR011237; Pept_M16_dom.
 IPR011765; Pept_M16_N.
 IPR007863; Peptidase_M16_C. 
Pfam
 PF00675; Peptidase_M16
 PF05193; Peptidase_M16_C 
SMART
  
PROSITE
 PS00143; INSULINASE 
PRINTS