UniProt Accession

 NR1H2_MOUSE; Q60644 

Genbank Protein ID

 U09419; AJ132602; BC066025 

Genbank Nucleotide ID

 AAC52164.1; CAB51924.1; AAH66025.1 

Protein Name

 Oxysterols receptor LXR-beta 

Protein Synonyms/Alias

 Liver X receptor beta; Nuclear receptor subfamily 1 group H member 2; Retinoid X receptor-interacting protein No.15; Ubiquitously-expressed nuclear receptor 

Gene Name

 Nr1h2 

Gene Synonyms/Alias

 Lxrb; Rip15; Unr; Unr2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
433	ALRLQDKKLPPLLSE	acetylation	[1]

Reference

 [1] SIRT1 deacetylates and positively regulates the nuclear receptor LXR.
 Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L.
 Mol Cell. 2007 Oct 12;28(1):91-106. [PMID: 17936707] 

Functional Description

 Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. 

Sequence Annotation

 DNA_BIND 75 152 Nuclear receptor.
 ZN_FING 78 98 NR C4-type.
 ZN_FING 116 140 NR C4-type.
 REGION 216 446 Ligand-binding (Potential).  

Keyword

 Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 446 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:MGI.
 GO:0046965; F:retinoid X receptor binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0001133; F:sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity; IEA:Compara.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0044255; P:cellular lipid metabolic process; IDA:MGI.
 GO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL.
 GO:0010887; P:negative regulation of cholesterol storage; IEA:Compara.
 GO:0032369; P:negative regulation of lipid transport; IEA:Compara.
 GO:0048550; P:negative regulation of pinocytosis; IEA:Compara.
 GO:0045861; P:negative regulation of proteolysis; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0032270; P:positive regulation of cellular protein metabolic process; IEA:Compara.
 GO:0010875; P:positive regulation of cholesterol efflux; IDA:BHF-UCL.
 GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Compara.
 GO:0090108; P:positive regulation of high-density lipoprotein particle assembly; IDA:BHF-UCL.
 GO:0010884; P:positive regulation of lipid storage; IMP:BHF-UCL.
 GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Compara.
 GO:0090187; P:positive regulation of pancreatic juice secretion; IMP:BHF-UCL.
 GO:0090340; P:positive regulation of secretion of lysosomal enzymes; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; IEA:Compara.
 GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Compara. 

Interpro

 IPR023257; Liver_X_rcpt.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00104; Hormone_recep
 PF00105; zf-C4 

SMART

 SM00430; HOLI
 SM00399; ZnF_C4 

PROSITE

 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 

PRINTS

 PR02034; LIVERXRECPTR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.