UniProt Accession

 KHK_HUMAN; P50053; Q6IBK2; Q99532; Q9BRJ3; Q9UMN1 

Genbank Protein ID

 X78678; X78677; CR456801; AC013403; CH471053; BC006233; Y09336; Y09341; Y09341; Y09340; AJ005168 

Genbank Nucleotide ID

 CAA55347.1; CAA55346.1; CAG33082.1; AAX93167.1; EAX00643.1; AAH06233.1; CAA70516.1; CAA70522.1; CAA70523.1; CAA70521.1; CAA06409.1 

Protein Name

 Ketohexokinase 

Protein Synonyms/Alias

 Hepatic fructokinase 

Gene Name

 KHK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
134	KVDLTQFKWIHIEGR	ubiquitination	[1, 2, 3]
148	RNASEQVKMLQRIDA	ubiquitination	[2]
197	FVSKDVAKHLGFQSA	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 NP_BIND 255 258 ATP.
 BINDING 15 15 D-fructose.
 BINDING 41 41 D-fructose; via amide nitrogen.
 BINDING 42 42 D-fructose.
 BINDING 45 45 D-fructose.
 BINDING 108 108 ATP.
 BINDING 258 258 D-fructose.
 MOD_RES 169 169 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Carbohydrate metabolism; Complete proteome; Disease mutation; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004454; F:ketohexokinase activity; EXP:Reactome.
 GO:0006001; P:fructose catabolic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR011611; PfkB_dom. 

Pfam

 PF00294; PfkB 

SMART

  

PROSITE

 PS00583; PFKB_KINASES_1
 PS00584; PFKB_KINASES_2 

PRINTS