CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030840
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 165 
Protein Synonyms/Alias
 cDNA FLJ60544, highly similar to Transmembrane protein TPARL 
Gene Name
 TMEM165 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
117RMLREGLKMSPDEGQubiquitination[1, 2, 3]
135EEVQAELKKKDEEFQubiquitination[1, 3]
145DEEFQRTKLLNGPGDubiquitination[1, 3, 4, 5]
164TSITVPQKKWLHFISubiquitination[1, 3, 4]
165SITVPQKKWLHFISPubiquitination[5]
231GGRMIAQKISVRTVTubiquitination[4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 261 AA 
Protein Sequence
MEIPMQKIFT PAAPVHTNKE DPATQTNLGF IHAFVAAISV IIVSELGDKT FFIAAIMAMR 60
YNRLTVLAGA MLALGLMTCL SVLFGYATTV IPRVYTYYVS TVLFAIFGIR MLREGLKMSP 120
DEGQEELEEV QAELKKKDEE FQRTKLLNGP GDVETGTSIT VPQKKWLHFI SPIFVQALTL 180
TFLAEWGDRS QLTTIVLAAR EDPYGVAVGG TVGHCLCTGL AVIGGRMIAQ KISVRTVTII 240
GGIVFLAFAF SALFISPDSG F 261 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR001727; UPF0016. 
Pfam
 PF01169; UPF0016 
SMART
  
PROSITE
 PS01214; UPF0016 
PRINTS