| Tag | Content |
|---|
| CPLM ID | CPLM-001063 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | General transcription factor IIH subunit 4 |
Protein Synonyms/Alias | Basic transcription factor 2 52 kDa subunit; BTF2 p52; General transcription factor IIH polypeptide 4; TFIIH basal transcription factor complex p52 subunit |
Gene Name | Gtf2h4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 82 | WVKKEFSKAQEESTG | ubiquitination | [1] | | 141 | TSQLGPDKHARDVPS | ubiquitination | [1] | | 379 | RAHPVMLKQNPVLPP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. |
Sequence Annotation | |
Keyword | Complete proteome; DNA damage; DNA repair; Nucleus; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 463 AA |
Protein Sequence | MEITPARGGL NRAHLQCRNL QEFLGGLSPG VLDRLYGHPA TCLAVFRELP SLAKNWVMRM 60
LFLEQPLPQA AVALWVKKEF SKAQEESTGL LSGLRIWHTQ LLPGGLQGLI LNPVFRQNLR 120
IALLGGGKAW SDDTSQLGPD KHARDVPSLD KYAEERWEVV LHFMVGSPSA AVSQDLAQLL 180
SQAGLMKSTE PGEPPCITSA GFQFLLLDTP AQLWYFMLQY LQTAQSRGMD LVEILSFLFQ 240
LSFSTLGKDY SVEGMSDSLL NFLQHLREFG LVFQRKRKSR RYYPTRLAIN LSSGVSGAGG 300
TVHQPGFIVV ETNYRLYAYT ESELQIALIA LFSEMLYRFP NMVVAQVTRE SVQQAIASGI 360
TAQQIIHFLR TRAHPVMLKQ NPVLPPTITD QIRLWELERD RLRFTEGVLY NQFLSQVDFE 420
LLLAHARELG VLVFENSAKR LMVVTPAGHS DVKRFWKRQK HSS 463 |
Gene Ontology | GO:0000439; C:core TFIIH complex; IEA:InterPro. GO:0005675; C:holo TFIIH complex; ISS:UniProtKB. GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro. GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:Compara. GO:0006289; P:nucleotide-excision repair; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006366; P:transcription from RNA polymerase II promoter; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |