UniProt Accession

 4EBP1_HUMAN; Q13541; B2R502; D3DSW8; Q6IBN3 

Genbank Protein ID

 L36055; AB044548; BT007162; CR456769; AK312011; CH471080; CH471080; BC004459; BC058073 

Genbank Nucleotide ID

 AAA62269.1; BAB18650.1; AAP35826.1; CAG33050.1; BAG34949.1; EAW63341.1; EAW63342.1; AAH04459.1; AAH58073.1 

Protein Name

 Eukaryotic translation initiation factor 4E-binding protein 1 

Protein Synonyms/Alias

 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I 

Gene Name

 EIF4EBP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	CRNSPVTKTPPRDLP	phosphoglycerylation	[1]

Reference

 [1] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237] 

Functional Description

 Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 37 37 Phosphothreonine; by MTOR.
 MOD_RES 41 41 Phosphothreonine.
 MOD_RES 46 46 Phosphothreonine; by MTOR.
 MOD_RES 50 50 Phosphothreonine.
 MOD_RES 54 54 Phosphotyrosine.
 MOD_RES 65 65 Phosphoserine; by DYRK2, MAPK1, MAPK3 and
 MOD_RES 70 70 Phosphothreonine; by MTOR.
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 101 101 Phosphoserine; by DYRK2.
 MOD_RES 112 112 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Protein synthesis inhibitor; Reference proteome; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:UniProtKB.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0031333; P:negative regulation of protein complex assembly; IEA:Compara.
 GO:0045947; P:negative regulation of translational initiation; IEA:Compara.
 GO:0045931; P:positive regulation of mitotic cell cycle; IMP:UniProtKB.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0031929; P:TOR signaling cascade; IDA:UniProtKB.
 GO:0006413; P:translational initiation; TAS:Reactome. 

Interpro

 IPR008606; EIF4EBP. 

Pfam

 PF05456; eIF_4EBP 

SMART

  

PROSITE

  

PRINTS