UniProt Accession

 QCR8_HUMAN; O14949; Q5FVE2; Q9BV88; Q9T2V7 

Genbank Protein ID

 D50369; BC001390; BC090048 

Genbank Nucleotide ID

 BAA23321.1; AAH01390.1; AAH90048.1 

Protein Name

 Cytochrome b-c1 complex subunit 8 

Protein Synonyms/Alias

 Complex III subunit 8; Complex III subunit VIII; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C 

Gene Name

 UQCRQ 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	AYPHVFTKGIPNVLR	ubiquitination	[1, 2, 3, 4]
73	EFERSKRKNPAAYEN	ubiquitination	[5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. 

Sequence Annotation

 CROSSLNK 33 33 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Direct protein sequencing; Disease mutation; Electron transport; Isopeptide bond; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Respiratory chain; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 82 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
 GO:0008121; F:ubiquinol-cytochrome-c reductase activity; IEA:InterPro.
 GO:0021680; P:cerebellar Purkinje cell layer development; IEA:Compara.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0021854; P:hypothalamus development; IEA:Compara.
 GO:0030901; P:midbrain development; IEA:Compara.
 GO:0021548; P:pons development; IEA:Compara.
 GO:0021860; P:pyramidal neuron development; IEA:Compara.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0021539; P:subthalamus development; IEA:Compara.
 GO:0021794; P:thalamus development; IEA:Compara. 

Interpro

 IPR004205; Cyt_bc1_su8. 

Pfam

 PF02939; UcrQ 

SMART

  

PROSITE

  

PRINTS