CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013137
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Quinone oxidoreductase-like protein 2 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
36AALCTELKQPLTIQEacetylation[1, 2, 3]
201AATGSDEKCKLAVQRacetylation[4]
201AATGSDEKCKLAVQRsuccinylation[4]
203TGSDEKCKLAVQRGAacetylation[1]
302QDFAVFSKSMSTAMQacetylation[1, 2, 3]
325PHTGAVFKLEKINDAacetylation[3]
328GAVFKLEKINDAFLHacetylation[1, 2, 3, 4]
328GAVFKLEKINDAFLHsuccinylation[4]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 350 AA 
Protein Sequence
MAARLCTRCL PPVWLCRQAW QGQGRHYRAA LCTELKQPLT IQEVAPRPVG PQEVRVDVHF 60
CGVNFADILA CRGQYQEKPP LPFTPGMEFS GAVLETGTDV STVKKGDRVI GVSSFHAMAE 120
QCITDQKTLW RIPENVSLQD AAVLPVSYGT AILAVDHRAR IQPGETVLVT AAAGATGLAV 180
IDVATNVFRA KVIAATGSDE KCKLAVQRGA QFSVNYSQGS LRDAVKKLAG SGGVNVAIDM 240
VGGDVFLESL RSLAWEGRIV VLGFAGGNIA SVPSNLLLLK NISAMGLYWG RYQHQDFAVF 300
SKSMSTAMQY CQQGLIHPHT GAVFKLEKIN DAFLHVMQRK STGKVLLSLK 350 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF08240; ADH_N
 PF00107; ADH_zinc_N 
SMART
  
PROSITE
  
PRINTS