| Tag | Content |
|---|
| CPLM ID | CPLM-023998 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synphilin-1 |
Protein Synonyms/Alias | Sph1; Alpha-synuclein-interacting protein |
Gene Name | SNCAIP |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 308 | QSKDFLNKTFSDPHG | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. |
Sequence Annotation | REPEAT 349 380 ANK 1.
REPEAT 384 413 ANK 2.
REPEAT 419 448 ANK 3.
REPEAT 456 485 ANK 4.
REPEAT 603 632 ANK 5.
REPEAT 699 729 ANK 6. |
Keyword | 3D-structure; Alternative splicing; ANK repeat; Coiled coil; Complete proteome; Cytoplasm; Neurodegeneration; Parkinson disease; Parkinsonism; Polymorphism; Reference proteome; Repeat; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 919 AA |
Protein Sequence | MEAPEYLDLD EIDFSDDISD NRSQGNRLQK LGLEDTDRED AMGFGSHRAK LTVVAALGAC 60
HCPENEYSVT SLKTIPELCR RCDTQNEDRS VSSSSWNCGI STLITNTQKP TGIADVYSKF 120
RPVKRVSPLK HQPETLENNE SDDQKNQKVV EYQKGGESDL GPQPQELGPG DGVGGPPGKS 180
SEPSTSLGEL EHYDLDMDEI LDVPYIKSSQ QLASFTKVTS EKRILGLCTT INGLSGKACS 240
TGSSESSSSN MAPFCVLSPV KSPHLRKASA VIHDQHKLST EETEISPPLV KCGSAYEPEN 300
QSKDFLNKTF SDPHGRKVEK TTPDCQLRAF HLQSSAAESK PEEQVSGLNR TSSQGPEERS 360
EYLKKVKSIL NIVKEGQISL LPHLAADNLD KIHDENGNNL LHIAASQGHA ECLQHLTSLM 420
GEDCLNERNT EKLTPAGLAI KNGQLECVRW MVSETEAIAE LSCSKDFPSL IHYAGCYGQE 480
KILLWLLQFM QEQGISLDEV DQDGNSAVHV ASQHGYLGCI QTLVEYGANV TMQNHAGEKP 540
SQSAERQGHT LCSRYLVVVE TCMSLASQVV KLTKQLKEQT VERVTLQNQL QQFLEAQKSE 600
GKSLPSSPSS PSSPASRKSQ WKSPDADDDS VAKSKPGVQE GIQVLGSLSA SSRARPKAKD 660
EDSDKILRQL LGKEISENVC TQEKLSLEFQ DAQASSRNSK KIPLEKRELK LARLRQLMQR 720
SLSESDTDSN NSEDPKTTPV RKADRPRPQP IVESVESMDS AESLHLMIKK HTLASGGRRF 780
PFSIKASKSL DGHSPSPTSE SSEPDLESQY PGSGSIPPNQ PSGDPQQPSP DSTAAQKVAT 840
SPKSALKSPS SKRRTSQNLK LRVTFEEPVV QMEQPSLELN GEKDKDKGRT LQRTSTSNES 900
GDQLKRPFGA FRSIMETLSG NQNNNNNYQA ANQLKTSTLP LTSLGRKTDA KGNPASSASK 960
GKNKAEMYSS CINLSSNMLI EEHLCNDTRH NDINRKMKKS YSIKHIAEPE SKELFL 1016 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |