UniProt Accession

 TYB4_RAT; P62329; P01253; P01254; Q0P5V6; Q63576 

Genbank Protein ID

 M34043; K01334; M26759; BC058137 

Genbank Nucleotide ID

 AAA42062.1; AAA42245.1; AAA42246.1; AAH58137.1 

Protein Name

 Thymosin beta-4 

Protein Synonyms/Alias

 T beta 4; Hematopoietic system regulatory peptide; Seraspenide 

Gene Name

 Tmsb4x 

Gene Synonyms/Alias

 Thyb4; Tmsb4 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MSDKPDMAEIE	acetylation	[1]
12	PDMAEIEKFDKSKLK	acetylation	[1]
26	KKTETQEKNPLPSKE	acetylation	[1]
32	EKNPLPSKETIEQEK	acetylation	[1]
39	KETIEQEKQAGES**	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 26 26 N6-acetyllysine (By similarity).
 MOD_RES 39 39 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 44 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0001649; P:osteoblast differentiation; IEP:RGD.
 GO:0042989; P:sequestering of actin monomers; TAS:RGD. 

Interpro

 IPR001152; Thymosin_b4.
 IPR016323; Thymosin_b4_chordata. 

Pfam

 PF01290; Thymosin 

SMART

 SM00152; THY 

PROSITE

 PS00500; THYMOSIN_B4 

PRINTS