UniProt Accession

 NEUM_HUMAN; P17677; A8K0Y4 

Genbank Protein ID

 M25667; S66541; S66533; S66534; AY842481; AK289699; AK290100; AC012598; AC092468; AC119795; BC007936 

Genbank Nucleotide ID

 AAA52516.1; AAB28649.1; AAB28649.1; AAB28649.1; AAV88094.1; BAF82388.1; BAF82789.1; AAH07936.1 

Protein Name

 Neuromodulin 

Protein Synonyms/Alias

 Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46 

Gene Name

 GAP43 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	EKNDDDQKIEQDGIK	ubiquitination	[1]
26	KIEQDGIKPEDKAHK	ubiquitination	[1]
30	DGIKPEDKAHKAATK	ubiquitination	[1]
37	KAHKAATKIQASFRG	ubiquitination	[1, 2]
113	ETPSEEKKGEGDAAT	ubiquitination	[1]
134	APASSEEKAGSAETE	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. 

Sequence Annotation

 DOMAIN 31 60 IQ.
 REGION 1 4 Important for membrane binding.
 MOD_RES 41 41 Phosphoserine; by PHK and PKC (By
 MOD_RES 94 94 Phosphothreonine (By similarity).
 MOD_RES 181 181 Phosphothreonine (By similarity).
 MOD_RES 202 202 Phosphoserine; by CK2 (By similarity).
 MOD_RES 203 203 Phosphoserine; by CK2 (By similarity).
 LIPID 3 3 S-palmitoyl cysteine (By similarity).
 LIPID 4 4 S-palmitoyl cysteine (By similarity).  

Keyword

 Alternative splicing; Calmodulin-binding; Cell junction; Cell membrane; Cell projection; Complete proteome; Developmental protein; Differentiation; Growth regulation; Lipoprotein; Membrane; Neurogenesis; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 238 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0031527; C:filopodium membrane; IDA:UniProtKB.
 GO:0032584; C:growth cone membrane; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0016198; P:axon choice point recognition; IEA:Compara.
 GO:0045165; P:cell fate commitment; IEA:Compara.
 GO:0010001; P:glial cell differentiation; IEA:Compara.
 GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; TAS:ProtInc.
 GO:0051489; P:regulation of filopodium assembly; IDA:UniProtKB.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0009611; P:response to wounding; TAS:ProtInc.
 GO:0042246; P:tissue regeneration; IEA:Compara. 

Interpro

 IPR000048; IQ_motif_EF-hand-BS.
 IPR001422; Neuromodulin.
 IPR017454; Neuromodulin_C.
 IPR018947; Neuromodulin_gap-junction_N.
 IPR018243; Neuromodulin_palmitoyl/P_site. 

Pfam

 PF00612; IQ
 PF06614; Neuromodulin
 PF10580; Neuromodulin_N 

SMART

 SM00015; IQ 

PROSITE

 PS50096; IQ
 PS00412; NEUROMODULIN_1
 PS00413; NEUROMODULIN_2 

PRINTS

 PR00215; NEUROMODULIN.