UniProt Accession

 E7EQ83_HUMAN; E7EQ83 

Genbank Protein ID

 AL121755; AL121924 

Genbank Nucleotide ID

  

Protein Name

 Phosphatidate cytidylyltransferase 

Protein Synonyms/Alias

  

Gene Name

 CDS2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
133	FGRTPLIKLSPKKTW	ubiquitination	[1]
208	IQSVIGWKTVRMYPF	ubiquitination	[1]
247	FKRAFKIKDFANTIP	ubiquitination	[2]
315	LRSHLIDKGMLTSTT	ubiquitination	[1, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Nucleotidyltransferase; Reference proteome; Transferase; Transmembrane. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 325 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004605; F:phosphatidate cytidylyltransferase activity; IEA:EC.
 GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR000374; PC_trans. 

Pfam

 PF01148; CTP_transf_1 

SMART

  

PROSITE

 PS01315; CDS 

PRINTS