UniProt Accession

 SERB_HUMAN; P78330; B2RCR5; Q7Z3S5 

Genbank Protein ID

 Y10275; AK315235; BX537439; CH471140; BC063614 

Genbank Nucleotide ID

 CAA71318.1; BAG37662.1; CAD97681.1; EAX07968.1; AAH63614.1 

Protein Name

 Phosphoserine phosphatase 

Protein Synonyms/Alias

 PSP; PSPase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase 

Gene Name

 PSPH 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
158	PTAESGGKGKVIKLL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. 

Sequence Annotation

 REGION 109 110 Substrate binding.
 ACT_SITE 20 20 Nucleophile.
 ACT_SITE 22 22 Proton donor.
 METAL 20 20 Magnesium.
 METAL 22 22 Magnesium; via carbonyl oxygen.
 METAL 179 179 Magnesium.
 BINDING 29 29 Substrate.
 BINDING 65 65 Substrate.
 BINDING 158 158 Substrate.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; Amino-acid biosynthesis; Complete proteome; Disease mutation; Hydrolase; Magnesium; Metal-binding; Phosphoprotein; Reference proteome; Serine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 225 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005509; F:calcium ion binding; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0004647; F:phosphoserine phosphatase activity; IDA:UniProtKB.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0006564; P:L-serine biosynthetic process; IBA:RefGenome.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0033574; P:response to testosterone stimulus; IEA:Compara. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006383; HAD-SF_hydro_IB_PSP-like.
 IPR023190; Pser_Pase_dom_2.
 IPR004469; SerB. 

Pfam

 PF00702; Hydrolase 

SMART

  

PROSITE

  

PRINTS