UniProt Accession

 TRADD_MOUSE; Q3U0V2 

Genbank Protein ID

 AK156540; BC132607 

Genbank Nucleotide ID

 BAE33749.1; AAI32608.1 

Protein Name

 Tumor necrosis factor receptor type 1-associated DEATH domain protein 

Protein Synonyms/Alias

 TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain 

Gene Name

 Tradd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
143	LNYILAQKPDRLRDE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. 

Sequence Annotation

 DOMAIN 213 303 Death.
 REGION 220 287 Interaction with KRT14 and KRT18 (By
 MOTIF 147 163 Nuclear export signal.
 MOTIF 229 242 Nuclear localization signal.  

Keyword

 Apoptosis; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 310 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043235; C:receptor complex; IEA:Compara.
 GO:0060090; F:binding, bridging; IEA:Compara.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:InterPro.
 GO:0051798; P:positive regulation of hair follicle development; IMP:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:InterPro. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR009095; TRADD_N. 

Pfam

 PF00531; Death
 PF09034; TRADD_N 

SMART

 SM00005; DEATH 

PROSITE

 PS50017; DEATH_DOMAIN 

PRINTS