CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013185
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rab-like protein 6 
Protein Synonyms/Alias
 GTP-binding protein Parf; Partner of ARF; Rab-like protein 1; RBEL1 
Gene Name
 RABL6 
Gene Synonyms/Alias
 C9orf86; PARF 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MFSALKKLVGSDQAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. 
Sequence Annotation
 NP_BIND 50 57 GTP (Potential).
 NP_BIND 100 104 GTP (Potential).
 NP_BIND 177 179 GTP (Potential).
 REGION 39 279 Small GTPase-like.
 REGION 655 693 Interaction with CDKN2A.
 MOD_RES 402 402 Phosphoserine.
 MOD_RES 425 425 Phosphoserine.
 MOD_RES 427 427 Phosphoserine.
 MOD_RES 470 470 Phosphoserine (By similarity).
 MOD_RES 471 471 Phosphoserine (By similarity).
 MOD_RES 577 577 Phosphoserine.
 MOD_RES 596 596 Phosphoserine.
 MOD_RES 599 599 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Glycoprotein; GTP-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 729 AA 
Protein Sequence
MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG DRNTGKTALW 60
HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD VVDKGKCKKR GDGLKMENDP 120
QEAESEMALD AEFLDVYKNC NGVVMMFDIT KQWTFNYILR ELPKVPTHVP VCVLGNYRDM 180
GEHRVILPDD VRDFIDNLDS RPPGSSYFRY AESSMKNSFG LKYLHKFFNI PFLQLQRETL 240
LRQLETNQLD MDATLEELSV QQETEDQNYG IFLEMMEARS RGHASPLAAN GQSPSPGSQS 300
PVVPAGAVST GSSSPGTPQP APQLPLNAAP PSSVPPVPPS EALPPPACPS APAPRRSIIS 360
RLFGTSPATE AAPPPPEPVP AAEGPATVQS VEDFVPDDRL DRSFLEDTTP ARDEKKVGAK 420
AAQQDSDSDG EALGGNPMVA GFQDDVDLED QPRGSPPLPA GPVPSQDITL SSEEEAEVAA 480
PTKGPAPAPQ QCSEPETKWS SIPASKPRRG TAPTRTAAPP WPGGVSVRTG PEKRSSTRPP 540
AEMEPGKGEQ ASSSESDPEG PIAAQMLSFV MDDPDFESEG SDTQRRADDF PVRDDPSDVT 600
DEDEGPAEPP PPPKLPLPAF RLKNDSDLFG LGLEEAGPKE SSEEGKEGKT PSKEKKKKKK 660
KGKEEEEKAA KKKSKHKKSK DKEEGKEERR RRQQRPPRSR ERTAADELEA FLGGGAPGGR 720
HPGGGDYEEL 730 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR013684; MIRO-like.
 IPR027417; P-loop_NTPase.
 IPR001806; Small_GTPase. 
Pfam
 PF08477; Miro 
SMART
  
PROSITE
 PS51419; RAB 
PRINTS
 PR00449; RASTRNSFRMNG.