UniProt Accession

 LRRC3_HUMAN; Q9BY71; Q0VDJ2 

Genbank Protein ID

 AB058646; AY061857; AY358120; BC119648; BC119649 

Genbank Nucleotide ID

 BAB40229.1; AAL35741.1; AAQ88487.1; AAI19649.1; AAI19650.1 

Protein Name

 Leucine-rich repeat-containing protein 3 

Protein Synonyms/Alias

  

Gene Name

 LRRC3 

Gene Synonyms/Alias

 C21orf102; LRRC3A; UNQ9233/PRO31982 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
241	RRHLEYLKSLPSAPA	ubiquitination	[1]
250	LPSAPASKDPIGPGP	ubiquitination	[1, 2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 DOMAIN 33 64 LRRNT.
 REPEAT 65 86 LRR 1.
 REPEAT 89 110 LRR 2.
 REPEAT 114 135 LRR 3.
 REPEAT 136 157 LRR 4.  

Keyword

 Complete proteome; Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 257 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 

Pfam

 PF00560; LRR_1
 PF01462; LRRNT 

SMART

 SM00369; LRR_TYP
 SM00013; LRRNT 

PROSITE

 PS51450; LRR 

PRINTS