UniProt Accession

 GSTM4_RAT; P08009 

Genbank Protein ID

 J02744; L35330; BC059130 

Genbank Nucleotide ID

 AAA41292.1; AAB00123.1; AAH59130.1 

Protein Name

 Glutathione S-transferase Yb-3 

Protein Synonyms/Alias

 Chain 4; GST Yb3; GST class-mu 3 

Gene Name

 Gstm3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
52	QWLNEKFKLGLDFPN	acetylation	[1]
69	YLIDGSHKITQSNAI	acetylation	[1]
199	KKISDYMKSSRFLPR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 DOMAIN 2 88 GST N-terminal.
 DOMAIN 90 208 GST C-terminal.
 REGION 7 8 Glutathione binding (By similarity).
 REGION 46 50 Glutathione binding (By similarity).
 REGION 59 60 Glutathione binding (By similarity).
 REGION 72 73 Glutathione binding (By similarity).
 BINDING 116 116 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0016529; C:sarcoplasmic reticulum; IEA:Compara.
 GO:0043295; F:glutathione binding; IEA:Compara.
 GO:0004364; F:glutathione transferase activity; IEA:EC.
 GO:0070458; P:cellular detoxification of nitrogen compound; IEA:Compara.
 GO:0071313; P:cellular response to caffeine; IEA:Compara.
 GO:0006749; P:glutathione metabolic process; IEA:Compara.
 GO:0060315; P:negative regulation of ryanodine-sensitive calcium-release channel activity; IEA:Compara.
 GO:0018916; P:nitrobenzene metabolic process; IEA:Compara.
 GO:0060316; P:positive regulation of ryanodine-sensitive calcium-release channel activity; IEA:Compara.
 GO:0010880; P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Compara.
 GO:0042178; P:xenobiotic catabolic process; IEA:Compara. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR003081; GST_mu.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01267; GSTRNSFRASEM.