CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022165
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA:m(4)X modification enzyme TRM13 homolog 
Protein Synonyms/Alias
 Coiled-coil domain-containing protein 76 
Gene Name
 TRMT13 
Gene Synonyms/Alias
 CCDC76 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
178LGNIENLKLLGPRRCubiquitination[1]
424GLLSVEEKKKIGHLCacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His) (By similarity). 
Sequence Annotation
 ZN_FING 59 79 CHHC-type.
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Metal-binding; Methyltransferase; Polymorphism; Reference proteome; Transferase; tRNA processing; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 481 AA 
Protein Sequence
MATSATSPHA PGFPAEGRCG YYVEKKKRFC RMVVAAGKRF CGEHAGAAEE EDARKRILCP 60
LDPKHTVYED QLAKHLKKCN SREKPKPDFY IQDINAGLRD ETEIPEQLVP ISSLSEEQLE 120
KLIKKLRKAS EGLNSTLKDH IMSHPALHDA LNDPKNGDSA TKHLKQQASI LGNIENLKLL 180
GPRRCFVEFG AGKGKLSHWV DIALKDAEKV HFILVEKVTT RFKVDGKHRK KNSVFERLQI 240
DIQHLCLNKI PVLREEKLPV VGIGKHLCGM ATDLALRCLV ETYAASFEER NEEPLAKRIK 300
NDKTEKEIYT LAKEGNEKNV PEKWNPVAGI VIALCCHHRC DWRHYVGKEY FRALGLGAVE 360
FHYFQRMSSW ATCGMRKTSL ETSNSTTKRQ DNQNDDSEEH DDGGYRITDD GADCLPGLLS 420
VEEKKKIGHL CKLLIDQGRI QYLQQKGFSP ALQYYTDPLV SLENVLLTAL PNHSSSPETT 480
A 481 
Gene Ontology
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR007871; Methyltransferase_TRM13.
 IPR022776; TRM13/UPF0224_CHHC_Znf_dom.
 IPR021721; Znf_CCCH-type_TRM13. 
Pfam
 PF05206; TRM13
 PF11722; zf-TRM13_CCCH
 PF05253; zf-U11-48K 
SMART
  
PROSITE
  
PRINTS