CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019583
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bile acid receptor 
Protein Synonyms/Alias
 Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14 
Gene Name
 NR1H4 
Gene Synonyms/Alias
 BAR; FXR; HRR1; RIP14 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
167FFRRSITKNAVYKCKacetylation[1]
227KRLRKNVKQHADQTVacetylation[1]
Reference
 [1] FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.
 Kemper JK, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, Tsang S, Wu SY, Chiang CM, Veenstra TD.
 Cell Metab. 2009 Nov;10(5):392-404. [PMID: 19883617] 
Functional Description
 Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. 
Sequence Annotation
 DNA_BIND 134 209 Nuclear receptor.
 ZN_FING 137 157 NR C4-type.
 ZN_FING 173 197 NR C4-type.
 REGION 256 474 Ligand-binding.
 REGION 342 350 Agonist binding (By similarity).
 BINDING 375 375 Agonist (By similarity).
 BINDING 383 383 Agonist (By similarity).
 BINDING 461 461 Agonist (By similarity).
 BINDING 483 483 Agonist (By similarity).
 MOD_RES 220 220 N6-methyllysine; by SETD7.  
Keyword
 3D-structure; Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Methylation; Nucleus; Receptor; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 486 AA 
Protein Sequence
MVMQFQGLEN PIQISPHCSC TPSGFFMEMM SMKPAKGVLT EQVAGPLGQN LEVEPYSQYS 60
NVQFPQVQPQ ISSSSYYSNL GFYPQQPEEW YSPGIYELRR MPAETLYQGE TEVAEMPVTK 120
KPRMGASAGR IKGDELCVVC GDRASGYHYN ALTCEGCKGF FRRSITKNAV YKCKNGGNCV 180
MDMYMRRKCQ ECRLRKCKEM GMLAECMYTG LLTEIQCKSK RLRKNVKQHA DQTVNEDSEG 240
RDLRQVTSTT KSCREKTELT PDQQTLLHFI MDSYNKQRMP QEITNKILKE EFSAEENFLI 300
LTEMATNHVQ VLVEFTKKLP GFQTLDHEDQ IALLKGSAVE AMFLRSAEIF NKKLPSGHSD 360
LLEERIRNSG ISDEYITPMF SFYKSIGELK MTQEEYALLT AIVILSPDRQ YIKDREAVEK 420
LQEPLLDVLQ KLCKIHQPEN PQHFACLLGR LTELRTFNHH HAEMLMSWRV NDHKFTPLLC 480
EIWDVQ 486 
Gene Ontology
 GO:0005719; C:nuclear euchromatin; IDA:BHF-UCL.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0038181; F:bile acid receptor activity; IDA:UniProtKB.
 GO:1902122; F:chenodeoxycholic acid binding; IDA:UniProtKB.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ISS:BHF-UCL.
 GO:0016922; F:ligand-dependent nuclear receptor binding; TAS:BHF-UCL.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0001190; F:RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; IDA:BHF-UCL.
 GO:0003707; F:steroid hormone receptor activity; IEA:Compara.
 GO:0004887; F:thyroid hormone receptor activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008206; P:bile acid metabolic process; IEA:Compara.
 GO:0071229; P:cellular response to acid; IDA:BHF-UCL.
 GO:0048565; P:digestive tract development; IEA:Compara.
 GO:0038185; P:intracellular bile acid receptor signaling pathway; IDA:UniProtKB.
 GO:0070858; P:negative regulation of bile acid biosynthetic process; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0001080; P:nitrogen catabolite activation of transcription from RNA polymerase II promoter; IC:BHF-UCL.
 GO:2001250; P:positive regulation of ammonia assimilation cycle; IEA:Compara.
 GO:2000213; P:positive regulation of glutamate metabolic process; ISS:BHF-UCL.
 GO:0006109; P:regulation of carbohydrate metabolic process; IEA:Compara.
 GO:0090181; P:regulation of cholesterol metabolic process; TAS:BHF-UCL.
 GO:0034255; P:regulation of urea metabolic process; ISS:BHF-UCL.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. 
Interpro
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001728; ThyrH_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.
 PR00546; THYROIDHORMR.