CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010139
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Tryptophan--tRNA ligase 
Protein Synonyms/Alias
 Tryptophanyl-tRNA synthetase; TrpRS 
Gene Name
 trpS 
Gene Synonyms/Alias
 MPN_265; MP568 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
223DPKEVVVKKIRQATTacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
  
Sequence Annotation
 MOTIF 11 19 "HIGH" region.
 MOTIF 200 204 "KMSKS" region.
 BINDING 203 203 ATP (By similarity).  
Keyword
 3D-structure; Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 346 AA 
Protein Sequence
MMKRALTGIQ ASGKQHLGNY LGVMQSLIEL QEQCQLFVFV ADLHSITVDF QPQALKQNNF 60
DLVRTLLAVG LDPQKACLFL QSDLLEHSMM GYLMMVQSNL GELQRMTQFK AKKAEQTRNP 120
NGTLNIPTGL LTYPALMAGD ILLYQPDIVP VGNDQKQHLE LTRDLAQRIQ KKFKLKLRLP 180
QFVQNKDTNR IMDLFDPTKK MSKSSKNQNG VIYLDDPKEV VVKKIRQATT DSFNKIRFAP 240
KTQPGVTNML TILKALLKEP VNQSLTNQLG NDLEAYFSTK SYLDLKNALT EATVNLLVNI 300
QRKREQISRE QVFNCLQAGK NQAQATARTT LALFYDGFGL GSQNIK 346 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004830; F:tryptophan-tRNA ligase activity; IEA:HAMAP.
 GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR002305; aa-tRNA-synth_Ic.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR002306; Trp-tRNA-ligase.
 IPR024109; Trp-tRNA-ligase_bac-type. 
Pfam
 PF00579; tRNA-synt_1b 
SMART
  
PROSITE
 PS00178; AA_TRNA_LIGASE_I 
PRINTS
 PR01039; TRNASYNTHTRP.