UniProt Accession

 SKA2_HUMAN; Q8WVK7; A6NIL3; B3KPL3; E9PCB8 

Genbank Protein ID

 AK056473; AC099850; CH471109; BC017873; BC106003; BI835364 

Genbank Nucleotide ID

 BAG51725.1; EAW94420.1; AAH17873.1; AAI06004.1 

Protein Name

 Spindle and kinetochore-associated protein 2 

Protein Synonyms/Alias

 Protein FAM33A 

Gene Name

 SKA2 

Gene Synonyms/Alias

 FAM33A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
65	QTLYARFKPVAVEQK	ubiquitination	[1]
72	KPVAVEQKESKSRIC	ubiquitination	[1]
94	NMIQKLQKQTDLELS	ubiquitination	[1]
105	LELSPLTKEEKTAAE	ubiquitination	[1]
115	KTAAEQFKFHMPDL*	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. 

Sequence Annotation

 MOD_RES 101 101 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 121 AA 

Protein Sequence

Gene Ontology

 GO:0000940; C:condensed chromosome outer kinetochore; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005876; C:spindle microtubule; IDA:UniProtKB.
 GO:0008017; F:microtubule binding; IDA:UniProtKB.
 GO:0051301; P:cell division; IMP:UniProtKB.
 GO:0007059; P:chromosome segregation; IMP:UniProtKB.
 GO:0000090; P:mitotic anaphase; IMP:UniProtKB.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0031110; P:regulation of microtubule polymerization or depolymerization; IDA:UniProtKB. 

Interpro

 IPR026762; Ska2. 

Pfam

  

SMART

  

PROSITE

  

PRINTS