| Tag | Content |
|---|
| CPLM ID | CPLM-020657 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Interleukin enhancer-binding factor 2 |
Protein Synonyms/Alias | Nuclear factor of activated T-cells 45 kDa |
Gene Name | Ilf2 |
Gene Synonyms/Alias | Nf45 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 45 | EMAFPRVKPAPDETS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Essential for the efficient reshuttling of ILF3 into the nucleus (By similarity). |
Sequence Annotation | DOMAIN 104 338 DZF.
MOD_RES 388 388 Phosphothreonine (By similarity). |
Keyword | 3D-structure; Activator; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 390 AA |
Protein Sequence | MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE TSFSEALLKR 60
NQDLAPNSAE QASILSLVTK INNVIDNLIV APGTFEVQIE EVRQVGSYKK GTMTTGHNVA 120
DLVVILKILP TLEAVAALGN KVVESLRAQD PSEVLTMLTN ETGFEISSSD ATVKILITTV 180
PPNLRKLDPE LHLDIKVLQS ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL 240
TPWILDLLGH YAVMNNPTRQ PLALNVAYRR CLQILAAGLF LPGSVGITDP CESGNFRVHT 300
VMTLEQQDMV CYTAQTLVRI LSHGGFRKIL GQEGDASYLA SEISTWDGVI VTPSEKAYEK 360
PPEKKEGEEE EENTEEPPQG EEEESMETQE 390 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005730; C:nucleolus; ISS:UniProtKB. GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:InterPro. GO:0003677; F:DNA binding; ISS:UniProtKB. GO:0003725; F:double-stranded RNA binding; ISS:UniProtKB. GO:0016740; F:transferase activity; IEA:InterPro. GO:0006955; P:immune response; IEA:InterPro. GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; ISS:UniProtKB. |
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PRINTS | |