UniProt Accession

 A7UKX7_HUMAN; A7UKX7 

Genbank Protein ID

 AC025423; EU076746 

Genbank Nucleotide ID

 ABT17083.1 

Protein Name

 E3 ubiquitin-protein ligase Mdm2 

Protein Synonyms/Alias

 Mdm2 

Gene Name

 mdm2 

Gene Synonyms/Alias

 MDM2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	RPKPLLLKLLKSVGA	ubiquitination	[1]
45	LKSVGAQKDTYTMKE	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:InterPro. 

Interpro

 IPR015459; MDM2_E3_ligase.
 IPR003121; SWIB_MDM2_domain. 

Pfam

  

SMART

  

PROSITE

  

PRINTS