UniProt Accession

 CDN2C_HUMAN; P42773; Q8TB83 

Genbank Protein ID

 U17074; AF041248; AF041250; AF041249; AY094608; BC000598; BC005041; BC016173 

Genbank Nucleotide ID

 AAC50074.1; AAC39782.1; AAC39783.1; AAC39783.1; AAM11873.1; AAH00598.1; AAH05041.1; AAH16173.1 

Protein Name

 Cyclin-dependent kinase 4 inhibitor C 

Protein Synonyms/Alias

 Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6 

Gene Name

 CDKN2C 

Gene Synonyms/Alias

 CDKN6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
136	NVGHRNHKGDTACDL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. 

Sequence Annotation

 REPEAT 4 33 ANK 1.
 REPEAT 37 65 ANK 2.
 REPEAT 69 98 ANK 3.
 REPEAT 102 132 ANK 4.  

Keyword

 3D-structure; ANK repeat; Cell cycle; Complete proteome; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 168 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IDA:BHF-UCL.
 GO:0007050; P:cell cycle arrest; IDA:BHF-UCL.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IDA:BHF-UCL.
 GO:0006917; P:induction of apoptosis; IDA:BHF-UCL.
 GO:0030308; P:negative regulation of cell growth; IDA:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.
 GO:0048709; P:oligodendrocyte differentiation; IEA:Compara.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:BHF-UCL. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 

Pfam

 PF00023; Ank 

SMART

 SM00248; ANK 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 

PRINTS