UniProt Accession

 AMACR_HUMAN; Q9UHK6; A5YM47; B8Y916; B8Y918; F8W9N1; O43673; Q3KT79; Q96GH1; Q9Y3Q1 

Genbank Protein ID

 AJ130733; AF158378; AY935981; AF047020; FJ498906; FJ498907; FJ498908; BT007193; EF560721; AC139783; CH471118; BC009471 

Genbank Nucleotide ID

 CAB44062.1; AAF22610.1; AAY16192.1; AAD10205.1; ACL67853.1; ACL67854.1; ACL67855.1; AAP35857.1; ABQ59031.1; EAX10816.1; AAH09471.1 

Protein Name

 Alpha-methylacyl-CoA racemase 

Protein Synonyms/Alias

 2-methylacyl-CoA racemase 

Gene Name

 AMACR 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	RSLVLDLKQPRGAAV	ubiquitination	[1]
87	FRRGVMEKLQLGPEI	ubiquitination	[1]
135	ALSGVLSKIGRSGEN	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. 

Sequence Annotation

 MOTIF 380 382 Microbody targeting signal.
 ACT_SITE 152 152 Nucleophile (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; Intrahepatic cholestasis; Isomerase; Mitochondrion; Peroxisome; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 382 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0005782; C:peroxisomal matrix; TAS:Reactome.
 GO:0005777; C:peroxisome; IDA:UniProtKB.
 GO:0008111; F:alpha-methylacyl-CoA racemase activity; IDA:UniProtKB.
 GO:0006699; P:bile acid biosynthetic process; TAS:Reactome.
 GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; TAS:Reactome. 

Interpro

 IPR003673; CoA-Trfase_fam_III.
 IPR023606; CoA-Trfase_III_dom. 

Pfam

 PF02515; CoA_transf_3 

SMART

  

PROSITE

  

PRINTS